SMER3 - ≥98%, high purity , CAS No.67200-34-4

  • ≥98%
Item Number
S275012
Grouped product items
SKUSizeAvailabilityPrice Qty
S275012-10mg
10mg
In stock
$107.90
S275012-50mg
50mg
In stock
$325.90
S275012-250mg
250mg
In stock
$1,467.90

Cell-permeable, selective SCF Met30 ubiquitin E3 ligase inhibitor

View related series
e3 ligase

Basic Description

Synonyms13-oxa-10,12,14,16-tetraazatetracyclo[7.7.0.0^{2,7}.0^{11,15}]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one | HY-10949 | Oprea1_783821 | US9073941, 28 | Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one | ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitro-2-thienyl)methyl]a
Specifications & Purity≥98%
Biochemical and Physiological MechanismsCell permeable, selective SCF Met30 ubiquitin E3 ligase inhibitor. Enhances the action of rapamycin. Induces cell cycles arrest (IC 50 = 10-30 μM). Active in vivo.
SourceSynthetic
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CTNNB1 Tchem Catenin beta-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGES Tchem Prostaglandin E synthase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DLAT Tbio Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BIRC5 Tchem Baculoviral IAP repeat-containing protein 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NQO1 Tchem NAD(P)H dehydrogenase [quinone] 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NQO1 Tchem Quinone reductase 1 (1746 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTNNB1 Tchem Catenin beta-1 (517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BIRC5 Tchem Baculoviral IAP repeat-containing protein 5 (144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L02 (4864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP C4-2 (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549/TR (299 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

PTGES Prostaglandin E synthase (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dlaT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (54 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one
INCHI InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChi Key SFSSAKVWCKFRHE-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
Isomeric SMILES C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
PubChem CID 568763
Molecular Weight 224.18

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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3 results found

Lot NumberCertificate TypeDateItem
G2229210Certificate of AnalysisMay 10, 2023 S275012
G2229211Certificate of AnalysisMay 10, 2023 S275012
G2229212Certificate of AnalysisMay 10, 2023 S275012

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM
SensitivityHeat sensitive
Melt Point(°C)296 °C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

Related Documents

Solution Calculators