SMI-4a - ≥98%, high purity , CAS No.438190-29-5

Item Number

T125988

• Synonyms: 5-(3-(Trifluoromethyl)benzylidene)thiazolidine-2,4-dione | 5-[[3-(trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione | EN300-55235 | SCHEMBL2541388 | (5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione | thiazolidine-2,4-dione,
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). TCS PIM-1 4a has been shown to display selectivity over a panel of approximately 50 other kinases tested. This compound a
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
A selective and ATP-competitive Pim kinase inhibitor