Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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S131283-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $49.90 | |
S131283-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $89.90 | |
S131283-100mg | 100mg | In stock | $159.90 | |
S131283-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $559.90 | |
S131283-1g | 1g | In stock | $999.90 |
NO donor
Synonyms | SNAP | KBioSS_001933 | N-ACETYL-3-(NITROSOTHIO)VALINE | SNAP (amino acid) | D-Valine,N-acetyl-3-(nitrosothio)- | KBio3_001666 | N-Acetyl-3-(nitrosothio)-DL-valine | S-Nitroso-N-acetyl-D,L-penicillamine | Spectrum2_001466 | SPBio_001391 | C4AX527AX8 | KBio |
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Specifications & Purity | ≥97% |
Biochemical and Physiological Mechanisms | NO donor; Vasodilator, smooth muscle relaxant, lymphocyte activator. Activate soluble guanylate cyclase.SNAP is a nitroso-mercaptan derivative that releases nitric oxide (NO) under physiological conditions, thus making it a useful tool for studying the ph |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid |
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INCHI | InChI=1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12) |
InChi Key | ZIIQCSMRQKCOCT-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)NC(C(=O)O)C(C)(C)SN=O |
Isomeric SMILES | CC(=O)NC(C(=O)O)C(C)(C)SN=O |
WGK Germany | 3 |
Alternate CAS | 79032-48-7 |
PubChem CID | 5231 |
Molecular Weight | 220.246 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2406504 | Certificate of Analysis | Jul 17, 2024 | S131283 |
H2406503 | Certificate of Analysis | Jul 17, 2024 | S131283 |
H2406502 | Certificate of Analysis | Jul 17, 2024 | S131283 |
H2406488 | Certificate of Analysis | Jul 17, 2024 | S131283 |
H2406489 | Certificate of Analysis | Jul 17, 2024 | S131283 |
H2406501 | Certificate of Analysis | Jul 17, 2024 | S131283 |
L2311289 | Certificate of Analysis | Nov 30, 2023 | S131283 |
C2427053 | Certificate of Analysis | Nov 30, 2023 | S131283 |
L2311280 | Certificate of Analysis | Nov 30, 2023 | S131283 |
L2311276 | Certificate of Analysis | Nov 30, 2023 | S131283 |
L2311274 | Certificate of Analysis | Nov 30, 2023 | S131283 |
G2222813 | Certificate of Analysis | Jun 09, 2022 | S131283 |
G2222806 | Certificate of Analysis | Jun 09, 2022 | S131283 |
G2222805 | Certificate of Analysis | Jun 09, 2022 | S131283 |
K2310027 | Certificate of Analysis | Jun 09, 2022 | S131283 |
G2222804 | Certificate of Analysis | Jun 09, 2022 | S131283 |
G2222796 | Certificate of Analysis | Jun 09, 2022 | S131283 |
E2324250 | Certificate of Analysis | Jun 09, 2022 | S131283 |
E2305067 | Certificate of Analysis | Jun 09, 2022 | S131283 |
Solubility | H2O: ≥2 mg/mL;DMSO: ≥20 mg/mL, clear, light green |
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Sensitivity | Moisture & Light sensitive |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
1. Hongqi Geng, Yaping Ren, Gang Qin, Tao Wen, Quan Liu, Haiyan Xu, Weiwei He. (2022) Ti3C2 nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress. RSC Advances, 12 (18): (11128-11138). [PMID:35425035] [10.1039/D2RA01225A] |
2. Jiawei Zhao, Yugang Wang, Wenjing Wang, Ying Tian, Zhongdong Gan, Yanlei Wang, Hongyan He, Wei Chen, Xiao Zhang, Yuanbin Wu, Rongrong Jia, Min Shi, Wei Wei, Guanghui Ma. (2021) In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases. Nano Today, 40 (101282). [PMID:] [10.1016/j.nantod.2021.101282] |
3. Jing Li, Xueqing Ma, Wei Yang, Chao Guo, Jingying Zhai, Xiaojiang Xie. (2021) Enhanced Sulfite-Selective Sensing and Cell Imaging with Fluorescent Nanoreactors Containing a Ratiometric Lipid Peroxidation Sensor. ANALYTICAL CHEMISTRY, 93 (34): (11758–11764). [PMID:34410685] [10.1021/acs.analchem.1c02167] |
4. Qifeng Li, Yalong Gao, Jun Shen, Xiaoyu Mu, Junying Wang, Lufei Ouyang, Ke Chen, Hua He, Jiahui Pei, Qinjuan Ren, Si Sun, Haile Liu, Lei Zhou, Yuanming Sun, Wei Long, Jianning Zhang, Xiao-Dong Zhang. (2021) Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury. Materials Today Communications, 27 (102286). [PMID:] [10.1016/j.mtcomm.2021.102286] |
5. Lufei Ouyang, Xiaoyu Mu, Junying Wang, Qifeng Li, Yalong Gao, Haile Liu, Si Sun, Qinjuan Ren, Ruijuan Yan, Jingya Wang, Qiang Liu, Yuanming Sun, Changlong Liu, Hua He, Wei Long, Xiao-Dong Zhang. (2020) Carbon dot targeting to nitrogen signaling molecules for inhibiting neuronal death. Journal of Materials Chemistry B, 8 (11): (2321-2330). [PMID:32100792] [10.1039/C9TB02447F] |
6. Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang. (2019) Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury. ACS Nano, 13 (2): (1870–1884). [PMID:30753061] [10.1021/acsnano.8b08045] |
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9. Jiawei Zhao, Yugang Wang, Wenjing Wang, Ying Tian, Zhongdong Gan, Yanlei Wang, Hongyan He, Wei Chen, Xiao Zhang, Yuanbin Wu, Rongrong Jia, Min Shi, Wei Wei, Guanghui Ma. (2021) In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases. Nano Today, 40 (101282). [PMID:] [10.1016/j.nantod.2021.101282] |
10. Jing Li, Xueqing Ma, Wei Yang, Chao Guo, Jingying Zhai, Xiaojiang Xie. (2021) Enhanced Sulfite-Selective Sensing and Cell Imaging with Fluorescent Nanoreactors Containing a Ratiometric Lipid Peroxidation Sensor. ANALYTICAL CHEMISTRY, 93 (34): (11758–11764). [PMID:34410685] [10.1021/acs.analchem.1c02167] |
11. Qifeng Li, Yalong Gao, Jun Shen, Xiaoyu Mu, Junying Wang, Lufei Ouyang, Ke Chen, Hua He, Jiahui Pei, Qinjuan Ren, Si Sun, Haile Liu, Lei Zhou, Yuanming Sun, Wei Long, Jianning Zhang, Xiao-Dong Zhang. (2021) Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury. Materials Today Communications, 27 (102286). [PMID:] [10.1016/j.mtcomm.2021.102286] |
12. Lufei Ouyang, Xiaoyu Mu, Junying Wang, Qifeng Li, Yalong Gao, Haile Liu, Si Sun, Qinjuan Ren, Ruijuan Yan, Jingya Wang, Qiang Liu, Yuanming Sun, Changlong Liu, Hua He, Wei Long, Xiao-Dong Zhang. (2020) Carbon dot targeting to nitrogen signaling molecules for inhibiting neuronal death. Journal of Materials Chemistry B, 8 (11): (2321-2330). [PMID:32100792] [10.1039/C9TB02447F] |
13. Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang. (2019) Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury. ACS Nano, 13 (2): (1870–1884). [PMID:30753061] [10.1021/acsnano.8b08045] |