SNAP [S-Nitroso-N-acetylpenicillamine] - ≥97%, high purity , CAS No.67776-06-1

  • ≥97%
Item Number
S131283
Grouped product items
SKUSizeAvailabilityPrice Qty
S131283-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
S131283-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$89.90
S131283-100mg
100mg
In stock
$159.90
S131283-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$559.90
S131283-1g
1g
In stock
$999.90

NO donor

Basic Description

SynonymsSNAP | KBioSS_001933 | N-ACETYL-3-(NITROSOTHIO)VALINE | SNAP (amino acid) | D-Valine,N-acetyl-3-(nitrosothio)- | KBio3_001666 | N-Acetyl-3-(nitrosothio)-DL-valine | S-Nitroso-N-acetyl-D,L-penicillamine | Spectrum2_001466 | SPBio_001391 | C4AX527AX8 | KBio
Specifications & Purity≥97%
Biochemical and Physiological MechanismsNO donor; Vasodilator, smooth muscle relaxant, lymphocyte activator. Activate soluble guanylate cyclase.SNAP is a nitroso-mercaptan derivative that releases nitric oxide (NO) under physiological conditions, thus making it a useful tool for studying the ph
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance.
Nitric oxide (NO) donor; vasodilator, smooth muscle relaxant, lymphocyte activator.

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid
INCHI InChI=1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)
InChi Key ZIIQCSMRQKCOCT-UHFFFAOYSA-N
Canonical SMILES CC(=O)NC(C(=O)O)C(C)(C)SN=O
Isomeric SMILES CC(=O)NC(C(=O)O)C(C)(C)SN=O
WGK Germany 3
Alternate CAS 79032-48-7
PubChem CID 5231
Molecular Weight 220.246

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot NumberCertificate TypeDateItem
H2406504Certificate of AnalysisJul 17, 2024 S131283
H2406503Certificate of AnalysisJul 17, 2024 S131283
H2406502Certificate of AnalysisJul 17, 2024 S131283
H2406488Certificate of AnalysisJul 17, 2024 S131283
H2406489Certificate of AnalysisJul 17, 2024 S131283
H2406501Certificate of AnalysisJul 17, 2024 S131283
L2311289Certificate of AnalysisNov 30, 2023 S131283
C2427053Certificate of AnalysisNov 30, 2023 S131283
L2311280Certificate of AnalysisNov 30, 2023 S131283
L2311276Certificate of AnalysisNov 30, 2023 S131283
L2311274Certificate of AnalysisNov 30, 2023 S131283
G2222813Certificate of AnalysisJun 09, 2022 S131283
G2222806Certificate of AnalysisJun 09, 2022 S131283
G2222805Certificate of AnalysisJun 09, 2022 S131283
K2310027Certificate of AnalysisJun 09, 2022 S131283
G2222804Certificate of AnalysisJun 09, 2022 S131283
G2222796Certificate of AnalysisJun 09, 2022 S131283
E2324250Certificate of AnalysisJun 09, 2022 S131283
E2305067Certificate of AnalysisJun 09, 2022 S131283

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Chemical and Physical Properties

SolubilityH2O: ≥2 mg/mL;DMSO: ≥20 mg/mL, clear, light green
SensitivityMoisture & Light sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

Citations of This Product

1. Hongqi Geng, Yaping Ren, Gang Qin, Tao Wen, Quan Liu, Haiyan Xu, Weiwei He.  (2022)  Ti3C2 nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress.  RSC Advances,  12  (18): (11128-11138).  [PMID:35425035] [10.1039/D2RA01225A]
2. Jiawei Zhao, Yugang Wang, Wenjing Wang, Ying Tian, Zhongdong Gan, Yanlei Wang, Hongyan He, Wei Chen, Xiao Zhang, Yuanbin Wu, Rongrong Jia, Min Shi, Wei Wei, Guanghui Ma.  (2021)  In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases.  Nano Today,  40  (101282).  [PMID:] [10.1016/j.nantod.2021.101282]
3. Jing Li, Xueqing Ma, Wei Yang, Chao Guo, Jingying Zhai, Xiaojiang Xie.  (2021)  Enhanced Sulfite-Selective Sensing and Cell Imaging with Fluorescent Nanoreactors Containing a Ratiometric Lipid Peroxidation Sensor.  ANALYTICAL CHEMISTRY,  93  (34): (11758–11764).  [PMID:34410685] [10.1021/acs.analchem.1c02167]
4. Qifeng Li, Yalong Gao, Jun Shen, Xiaoyu Mu, Junying Wang, Lufei Ouyang, Ke Chen, Hua He, Jiahui Pei, Qinjuan Ren, Si Sun, Haile Liu, Lei Zhou, Yuanming Sun, Wei Long, Jianning Zhang, Xiao-Dong Zhang.  (2021)  Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury.  Materials Today Communications,  27  (102286).  [PMID:] [10.1016/j.mtcomm.2021.102286]
5. Lufei Ouyang, Xiaoyu Mu, Junying Wang, Qifeng Li, Yalong Gao, Haile Liu, Si Sun, Qinjuan Ren, Ruijuan Yan, Jingya Wang, Qiang Liu, Yuanming Sun, Changlong Liu, Hua He, Wei Long, Xiao-Dong Zhang.  (2020)  Carbon dot targeting to nitrogen signaling molecules for inhibiting neuronal death.  Journal of Materials Chemistry B,  (11): (2321-2330).  [PMID:32100792] [10.1039/C9TB02447F]
6. Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang.  (2019)  Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury.  ACS Nano,  13  (2): (1870–1884).  [PMID:30753061] [10.1021/acsnano.8b08045]

References

1. Bright DP & Brickley SG.  (2008)  Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus..  J Physiol,  586  (Pt 21): (5091-9).  [PMID:18772202]
2. Oliver AA et al..  (2020)  Analysis of vascular inflammation against bioresorbable Zn-Ag based alloys..  ACS Appl Bio Mater,  (10): (6779-6789).  [PMID:33644704]
3. Fenselau H et al..  (2011)  Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons..  J Neurosci,  31  (48): (17383-91).  [PMID:22131400]
4. Elies J et al..  (2014)  Inhibition of the cardiac na+ channel nav1.5 by carbon monoxide..  J Biol Chem,  289  (23): (16421-9).  [PMID:24719320]
5. Zhou MH et al..  (2015)  Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation..  J Biol Chem,  290  (51): (30616-23).  [PMID:26507659]
6. Jin XG et al..  (2011)  Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons..  J Biol Chem,  286  (38): (33190-202).  [PMID:21813646]
7. Sieber AR et al..  (2013)  Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus..  J Neurosci,  33  (40): (15675-85).  [PMID:24089475]
8. Hongqi Geng, Yaping Ren, Gang Qin, Tao Wen, Quan Liu, Haiyan Xu, Weiwei He.  (2022)  Ti3C2 nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress.  RSC Advances,  12  (18): (11128-11138).  [PMID:35425035] [10.1039/D2RA01225A]
9. Jiawei Zhao, Yugang Wang, Wenjing Wang, Ying Tian, Zhongdong Gan, Yanlei Wang, Hongyan He, Wei Chen, Xiao Zhang, Yuanbin Wu, Rongrong Jia, Min Shi, Wei Wei, Guanghui Ma.  (2021)  In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases.  Nano Today,  40  (101282).  [PMID:] [10.1016/j.nantod.2021.101282]
10. Jing Li, Xueqing Ma, Wei Yang, Chao Guo, Jingying Zhai, Xiaojiang Xie.  (2021)  Enhanced Sulfite-Selective Sensing and Cell Imaging with Fluorescent Nanoreactors Containing a Ratiometric Lipid Peroxidation Sensor.  ANALYTICAL CHEMISTRY,  93  (34): (11758–11764).  [PMID:34410685] [10.1021/acs.analchem.1c02167]
11. Qifeng Li, Yalong Gao, Jun Shen, Xiaoyu Mu, Junying Wang, Lufei Ouyang, Ke Chen, Hua He, Jiahui Pei, Qinjuan Ren, Si Sun, Haile Liu, Lei Zhou, Yuanming Sun, Wei Long, Jianning Zhang, Xiao-Dong Zhang.  (2021)  Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury.  Materials Today Communications,  27  (102286).  [PMID:] [10.1016/j.mtcomm.2021.102286]
12. Lufei Ouyang, Xiaoyu Mu, Junying Wang, Qifeng Li, Yalong Gao, Haile Liu, Si Sun, Qinjuan Ren, Ruijuan Yan, Jingya Wang, Qiang Liu, Yuanming Sun, Changlong Liu, Hua He, Wei Long, Xiao-Dong Zhang.  (2020)  Carbon dot targeting to nitrogen signaling molecules for inhibiting neuronal death.  Journal of Materials Chemistry B,  (11): (2321-2330).  [PMID:32100792] [10.1039/C9TB02447F]
13. Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang.  (2019)  Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury.  ACS Nano,  13  (2): (1870–1884).  [PMID:30753061] [10.1021/acsnano.8b08045]

Solution Calculators