Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S275295-5mg | 5mg | In stock | $147.90 | |
S275295-10mg | 10mg | In stock | $236.90 | |
S275295-25mg | 25mg | In stock | $494.90 | |
S275295-50mg | 50mg | In stock | $840.90 |
Highly potent, selective δ opioid receptor agonist
Synonyms | UNII-L842QB22SW | CS-0020978 | DTXCID4025662 | NSC-759148 | 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide | Benzamide, 4-((2,5-dimethyl-4-(2-propenyl)-1-piperazinyl)(3-methoxyphenyl)methyl)-N,N-diethyl-, (2S-(1(S*),2a |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Highly potent and selective δ opioid receptor agonist (K i = 9.4 nM). Centrally active following systemic administration. Displays antidepressant activity. |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of δ receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide |
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INCHI | InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1 |
InChi Key | KQWVAUSXZDRQPZ-UMTXDNHDSA-N |
Canonical SMILES | CCN(CC)C(=O)C1=CC=C(C=C1)C(C2=CC(=CC=C2)OC)N3CC(N(CC3C)CC=C)C |
Isomeric SMILES | CCN(CC)C(=O)C1=CC=C(C=C1)[C@H](C2=CC(=CC=C2)OC)N3C[C@H](N(C[C@@H]3C)CC=C)C |
PubChem CID | 123924 |
Molecular Weight | 449.64 |
PubChem CID | 123924 |
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Wikipedia | SNC-80 |
BindingDB Ligand | 50039029 |
ChEMBL Ligand | CHEMBL13470 |
CAS Registry No. | 156727-74-1 |
GPCRdb Ligand | SNC80 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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B2318814 | Certificate of Analysis | Dec 25, 2023 | S275295 |
B2318744 | Certificate of Analysis | Dec 25, 2023 | S275295 |
B2318731 | Certificate of Analysis | Dec 21, 2023 | S275295 |
B2318751 | Certificate of Analysis | Dec 21, 2023 | S275295 |
Solubility | Soluble in 1 eq. HCl to 100 mM and in DMSO to 20 mM |
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1. Mann A et al.. (2020) Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies.. Sci Rep, 10 (8585). [PMID:32444688] |
2. Zeng X et al.. (2018) Contribution of TLR4 signaling in intermittent hypoxia-mediated atherosclerosis progression.. J Transl Med, 16 (106). [PMID:29673358] |