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SNC80 - ≥98% , high purity , CAS No.156727-74-1, Agonist of δ receptor

  • Moligand™
  • ≥98%
Item Number
S275295
Grouped product items
SKUSizeAvailabilityPrice Qty
S275295-5mg
5mg
In stock
$147.90
S275295-10mg
10mg
In stock
$236.90
S275295-25mg
25mg
In stock
$494.90
S275295-50mg
50mg
In stock
$840.90

Highly potent, selective δ opioid receptor agonist

View related series
δ receptor Agonist

Basic Description

SynonymsSnc 80|156727-74-1|Snc-80|SNC80|4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide|4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide|CHEMBL13470|L842QB22SW|DTXSID604566
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsHighly potent and selective δ opioid receptor agonist (K i = 9.4 nM). Centrally active following systemic administration. Displays antidepressant activity.
Storage TempRoom temperature
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of δ receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. The product can be stored for up to 12 months.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PMP22 Tbio Peripheral myelin protein 22 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 28 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
INCHI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
InChi Key KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Canonical SMILES CCN(CC)C(=O)C1=CC=C(C=C1)C(C2=CC(=CC=C2)OC)N3CC(N(CC3C)CC=C)C
Isomeric SMILES CCN(CC)C(=O)C1=CC=C(C=C1)[C@H](C2=CC(=CC=C2)OC)N3C[C@H](N(C[C@@H]3C)CC=C)C
PubChem CID 123924
Molecular Weight 449.64

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
B2318814Certificate of AnalysisDec 25, 2023 S275295
B2318744Certificate of AnalysisDec 25, 2023 S275295
B2318731Certificate of AnalysisDec 21, 2023 S275295
B2318751Certificate of AnalysisDec 21, 2023 S275295

Chemical and Physical Properties

SolubilitySoluble in 1 eq. HCl to 100 mM and in DMSO to 20 mM

Related Documents

References

1. Mann A et al..  (2020)  Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies..  Sci Rep,  10  (8585).  [PMID:32444688]
2. Zeng X et al..  (2018)  Contribution of TLR4 signaling in intermittent hypoxia-mediated atherosclerosis progression..  J Transl Med,  16  (106).  [PMID:29673358]

Solution Calculators