Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S126734-5mg | 5mg | In stock | $53.90 | |
S126734-10mg | 10mg | In stock | $75.90 | |
S126734-50mg | 50mg | In stock | $162.90 | |
S126734-100mg | 100mg | In stock | $271.90 | |
S126734-250mg | 250mg | In stock | $612.90 | |
S126734-1g | 1g | In stock | $2,203.90 |
Potent, selective cyclin-dependent kinase (CDK) inhibitor
Synonyms | HY-10008 | J-523350 | SNS-032 (BMS-387032) | 345627-80-7 (free base) | CHEBI:91399 | n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]-thio]-2-thiazolyl]-4-piperidinecarboxamide | N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperid |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | BMS-387032 is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). BMS-387032 displays no activity against 190 additional kinases (IC50 >1000 nM). BMS-387032 arrests the cell cycle at G2/M; in |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Cyclin-dependent kinase 9 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide |
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INCHI | InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) |
InChi Key | OUSFTKFNBAZUKL-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3 |
Isomeric SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3 |
PubChem CID | 3025986 |
Molecular Weight | 380.53 |
CAS Registry No. | 345627-80-7 |
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DiscoveRx TREEspot | BMS-387032/SNS-032| |
PubChem CID | 3025986 |
ChEMBL Ligand | CHEMBL296468 |
RCSB PDB Ligand | 56H |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2210331 | Certificate of Analysis | Sep 19, 2024 | S126734 |
L2210335 | Certificate of Analysis | Sep 19, 2024 | S126734 |
L2210338 | Certificate of Analysis | Sep 19, 2024 | S126734 |
L2210350 | Certificate of Analysis | Sep 19, 2024 | S126734 |
L2210352 | Certificate of Analysis | Sep 19, 2024 | S126734 |
L2210356 | Certificate of Analysis | Sep 19, 2024 | S126734 |
Solubility | DMSO 76 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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1. Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ et al.. (2004) N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.. J Med Chem, 47 (7): (1719-28). [PMID:15027863] [10.1021/op500134e] |
2. Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME. (2013) Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.. J Med Chem, 56 (3): (660-70). [PMID:23252711] [10.1021/op500134e] |