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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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S579505-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $19.90 | |
S579505-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $48.90 | |
S579505-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $128.90 | |
S579505-250g | 250g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $291.90 | |
S579505-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $539.90 |
Synonyms | Kybella | sodium (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oate | Deoxycholic acid sodium salt | HY-N0593A | Na-Desoxycholat | ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO |
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Specifications & Purity | ≥97% |
Biochemical and Physiological Mechanisms | Increase the dissolution of fat to promote its absorption in the intestine. A water-soluble ionic detergent used to extract membrane receptors and other plasma membrane proteins. Reportedly inducible β- Tyrosine phosphorylation of Catenin and subsequent t |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Note | 如果有可能,您尽量在同一天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
Product Description |
Deoxycholic acid sodium salt, also known as Sodium Deoxycholate, is a highly versatile ionic detergent utilized for its exceptional ability to solubilize membrane-bound proteins and lyse cells. Its mechanism involves disrupting cell membranes and dissolving hydrophobic molecules, making it an invaluable reagent in scientific research applications. In protein research, it plays a pivotal role in solubilizing proteins, particularly those embedded in membranes, enabling their extraction, purification, and subsequent analysis.
Moreover, Sodium Deoxycholate extends its utility to nucleic acid extraction from cells and tissues. By lysing cells and disrupting cellular structures, it facilitates the release and purification of nucleic acids, proving valuable in cell biology and biochemical research. Beyond these applications, its effectiveness in cell lysis processes positions it as a valuable tool for breaking down cells and releasing their contents, finding applications in diverse biological studies, encompassing microscopy, cell biology, and biochemical research.
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IUPAC Name | sodium;(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate |
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INCHI | InChI=1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1 |
InChi Key | FHHPUSMSKHSNKW-SMOYURAASA-M |
Canonical SMILES | CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C.[Na+] |
Isomeric SMILES | C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+] |
WGK Germany | 3 |
RTECS | FZ2250000 |
PubChem CID | 23668196 |
Molecular Weight | 414.56 |
Beilstein | 3581950 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2426417 | Certificate of Analysis | Aug 30, 2024 | S579505 |
H2426416 | Certificate of Analysis | Aug 30, 2024 | S579505 |
H2426415 | Certificate of Analysis | Aug 30, 2024 | S579505 |
H2426414 | Certificate of Analysis | Aug 30, 2024 | S579505 |
G2404251 | Certificate of Analysis | Jun 25, 2024 | S579505 |
G2404250 | Certificate of Analysis | Jun 25, 2024 | S579505 |
G2404249 | Certificate of Analysis | Jun 25, 2024 | S579505 |
D2415156 | Certificate of Analysis | Mar 30, 2024 | S579505 |
D2415155 | Certificate of Analysis | Mar 30, 2024 | S579505 |
D2415154 | Certificate of Analysis | Mar 30, 2024 | S579505 |
D2415153 | Certificate of Analysis | Mar 30, 2024 | S579505 |
B2401290 | Certificate of Analysis | Jan 23, 2024 | S579505 |
B2401295 | Certificate of Analysis | Jan 23, 2024 | S579505 |
B2401294 | Certificate of Analysis | Jan 23, 2024 | S579505 |
B2401293 | Certificate of Analysis | Jan 23, 2024 | S579505 |
B2401292 | Certificate of Analysis | Jan 23, 2024 | S579505 |
B2401291 | Certificate of Analysis | Jan 23, 2024 | S579505 |
B2401289 | Certificate of Analysis | Jan 23, 2024 | S579505 |
J2307101 | Certificate of Analysis | Sep 20, 2023 | S579505 |
J2307102 | Certificate of Analysis | Sep 20, 2023 | S579505 |
J2307103 | Certificate of Analysis | Sep 20, 2023 | S579505 |
D2314706 | Certificate of Analysis | Apr 19, 2023 | S579505 |
D2314466 | Certificate of Analysis | Apr 19, 2023 | S579505 |
D2314461 | Certificate of Analysis | Apr 19, 2023 | S579505 |
D2314459 | Certificate of Analysis | Apr 19, 2023 | S579505 |
D2314458 | Certificate of Analysis | Apr 19, 2023 | S579505 |
Solubility | Soluble in water (330 g/l) at 15 °C, DMSO, methanol, and ethanol (very slightly). |
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Sensitivity | Hygroscopic |
Specific Rotation[α] | 42° (C=2,H2O) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | FZ2250000 |
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1. Jing Zhang, Kairu Liu, Xiaojuan Duan, Xuhao Wang, Wupeng Ge, Wenping Jin. (2023) Restoration of Choujiu Koji and evaluation of its brewing performance. LWT-FOOD SCIENCE AND TECHNOLOGY, 183 (114933). [PMID:] |
2. Peng Weichao, Yan Shuaihu, Zhou Ke, Wu Hai-Chen, Liu Lei, Zhao Yuliang. (2023) High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes. Nature Communications, 14 (1): (1-8). [PMID:37160961] |
3. Sheng Liu, Bo Yang, Yingxiang Hou, Kaige Cui, Xiaozhu Yang, Xiaoxiong Li, Lianwan Chen, Shichao Liu, Zhichao Zhang, Yuanyuan Jia, Yufeng Xie, Ying Xue, Xiaomei Li, Bingxue Yan, Changxin Wu, Wen Deng, Jianxun Qi, Defen Lu, George F. Gao, Peiyi Wang, Guijun Shang. (2023) The mechanism of STING autoinhibition and activation. MOLECULAR CELL, 83 (1502-1518.e10). [PMID:37086726] |
4. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu. (2023) Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability. Drug Design Development and Therapy, [PMID:27895469] |
5. Chuntian Shao, Jingwei Zhong, Junwen Liu, Yiyan Yang, Meilin Li, Yang Yu, Yaqin Xu, Libo Wang. (2023) Preparation, characterization and bioactivities of selenized polysaccharides from Lonicera caerulea L. fruits. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 225 (484). [PMID:36403769] |
6. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang. (2022) Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 439 (129590). [PMID:35872451] |
7. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu. (2022) Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (14): (7666). [PMID:35887010] |
8. Wang Cong-Yu, Sun Min, Fan Zhen, Du Jian-Zhong. (2022) Intestine Enzyme-responsive Polysaccharide-based Hydrogel to Open Epithelial Tight Junctions for Oral Delivery of Imatinib against Colon Cancer. CHINESE JOURNAL OF POLYMER SCIENCE, 40 (10): (1154-1164). [PMID:] |
9. Chu-tong Tian, Jing-jing Guo, Yi-fan Miao, He-lin Wang, Qing Ye, Chun-lin Guo, Ming-yang Zhang, Zhong-gui He, Jin Sun. (2022) Long chain triglyceride-lipid formulation promotes the oral absorption of the lipidic prodrugs through coincident intestinal behaviors. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 176 (122). [PMID:35643367] |
10. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua. (2022) Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats. Journal of Ocean University of China, 21 (3): (782-788). [PMID:] |
1. Jing Zhang, Kairu Liu, Xiaojuan Duan, Xuhao Wang, Wupeng Ge, Wenping Jin. (2023) Restoration of Choujiu Koji and evaluation of its brewing performance. LWT-FOOD SCIENCE AND TECHNOLOGY, 183 (114933). [PMID:] |
2. Peng Weichao, Yan Shuaihu, Zhou Ke, Wu Hai-Chen, Liu Lei, Zhao Yuliang. (2023) High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes. Nature Communications, 14 (1): (1-8). [PMID:37160961] |
3. Sheng Liu, Bo Yang, Yingxiang Hou, Kaige Cui, Xiaozhu Yang, Xiaoxiong Li, Lianwan Chen, Shichao Liu, Zhichao Zhang, Yuanyuan Jia, Yufeng Xie, Ying Xue, Xiaomei Li, Bingxue Yan, Changxin Wu, Wen Deng, Jianxun Qi, Defen Lu, George F. Gao, Peiyi Wang, Guijun Shang. (2023) The mechanism of STING autoinhibition and activation. MOLECULAR CELL, 83 (1502-1518.e10). [PMID:37086726] |
4. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu. (2023) Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability. Drug Design Development and Therapy, [PMID:27895469] |
5. Chuntian Shao, Jingwei Zhong, Junwen Liu, Yiyan Yang, Meilin Li, Yang Yu, Yaqin Xu, Libo Wang. (2023) Preparation, characterization and bioactivities of selenized polysaccharides from Lonicera caerulea L. fruits. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 225 (484). [PMID:36403769] |
6. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang. (2022) Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 439 (129590). [PMID:35872451] |
7. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu. (2022) Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (14): (7666). [PMID:35887010] |
8. Wang Cong-Yu, Sun Min, Fan Zhen, Du Jian-Zhong. (2022) Intestine Enzyme-responsive Polysaccharide-based Hydrogel to Open Epithelial Tight Junctions for Oral Delivery of Imatinib against Colon Cancer. CHINESE JOURNAL OF POLYMER SCIENCE, 40 (10): (1154-1164). [PMID:] |
9. Chu-tong Tian, Jing-jing Guo, Yi-fan Miao, He-lin Wang, Qing Ye, Chun-lin Guo, Ming-yang Zhang, Zhong-gui He, Jin Sun. (2022) Long chain triglyceride-lipid formulation promotes the oral absorption of the lipidic prodrugs through coincident intestinal behaviors. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 176 (122). [PMID:35643367] |
10. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua. (2022) Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats. Journal of Ocean University of China, 21 (3): (782-788). [PMID:] |