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TK:Tyrosine kinase
Solcitinib - 98%, high purity , Tyrosine-protein kinase JAK1 inhibitor, CAS No.1206163-45-2, Tyrosine-protein kinase JAK1 inhibitor

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Solcitinib - 98%, high purity , Tyrosine-protein kinase JAK1 inhibitor, CAS No.1206163-45-2, Tyrosine-protein kinase JAK1 inhibitor

Moligand™

≥98%

CAS#: 1206163-45-2
Formula: C₂₂H₂₃N₅O₂
Molecular Weight: 389.45
PubChem CID: 44603362

Item Number

S413366

Grouped product items
SKU	Size	Availability	Price	Qty
S413366-5mg	5mg	In stock	$199.90
S413366-25mg	25mg	In stock	$686.90

JAK1 Selective Inhibitors

View related series

Janus kinase 1 Inhibitor Janus kinase 2 Inhibitor Janus kinase 3 Inhibitor tyrosine kinase 2 Inhibitor

Basic Description

Synonyms	AS-56075 \| A14405 \| A892157 \| GSK 2586184 \| NSC 59989 \| SB16965 \| GLPG-0778;Solcitinib \| MPYACSQFXVMWNO-UHFFFAOYSA-N \| VERATRALDEHYDE [FHFI] \| Q10395590 \| s5917 \| SOLCITINIB [WHO-DD] \| G154578 \| G-154578 \| GLPG-0788 \| Cyclopropanecarboxamide, N-(5-(4-((3,
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Tyrosine-protein kinase JAK1 inhibitor
Product Description	Information Solcitinib (GLPG0778, GSK2586184) is an inhibitor ofJAK1with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively. Targets JAK2 ; JAK3 ; TYK2 ; JAK1 ; 8-9 nM

Product Properties

ALogP	3.118
HBD Count	1
Rotatable Bond	4

Associated Targets(Human)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 (1 Activities)

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 (1 Activities)

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 (2 Activities)

Discover Target: JAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 (1 Activities)

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)

Discover Target: JAK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 Activities)

Discover Target: JAK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)

Discover Target: JAK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TYK2 Tclin Tyrosine-protein kinase TYK2 (5029 Activities)

Discover Target: TYK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[5-[4-(3,3-dimethylazetidine-1-carbonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
INCHI	InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)
InChi Key	MPYACSQFXVMWNO-UHFFFAOYSA-N
Canonical SMILES	CC1(CN(C1)C(=O)C2=CC=C(C=C2)C3=CC=CC4=NC(=NN43)NC(=O)C5CC5)C
Isomeric SMILES	CC1(CN(C1)C(=O)C2=CC=C(C=C2)C3=CC=CC4=NC(=NN43)NC(=O)C5CC5)C
PubChem CID	44603362
Molecular Weight	389.45

Database links

PubChem CID	44603362
CAS Registry No.	1206163-45-2
ChEMBL Ligand	CHEMBL3301606
BitterDB Ligand	128101

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
F2218528	Certificate of Analysis	Apr 02, 2024	S413366
F2218530	Certificate of Analysis	Apr 02, 2024	S413366

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 30 mg/mL (77.03 mM); Ethanol: 3 mg/mL (7.7 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	30
DMSO(mM) Max Solubility	77.0317113878547
Water(mg / mL) Max Solubility	＜1

References

1. Kahl L, Patel J, Layton M, Binks M, Hicks K, Leon G, Hachulla E, Machado D, Staumont-Sallé D, Dickson M et al.. (2016) Safety, tolerability, efficacy and pharmacodynamics of the selective JAK1 inhibitor GSK2586184 in patients with systemic lupus erythematosus.. Lupus, 25 (13): (1420-1430). [PMID:27055521]
2. Ludbrook VJ, Hicks KJ, Hanrott KE, Patel JS, Binks MH, Wyres MR, Watson J, Wilson P, Simeoni M, Schifano LA et al.. (2016) Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study.. Br J Dermatol, 174 (5): (985-95). [PMID:26785220]

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