sorbinil , Aldose reductase inhibitor, CAS No.68367-52-2, Aldose reductase inhibitor

Item Number
S613657
Grouped product items
SKUSizeAvailabilityPrice Qty
S613657-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
S613657-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90

Basic Description

SynonymsQ1259458 | SORBINIL [WHO-DD] | CCG-221489 | Sorbinilo | Sorbinilo [Spanish] | (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione | HMS3260F11 | NSC 355082 | Sorbinil [USAN:INN:BAN] | Sorbinilum [Latin] | Sorbinil | (S)-6-Fluorospiro(ch
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionAldose reductase inhibitor

Associated Targets(Human)

AKR1B1 Tclin Aldose reductase (18 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AKR1B1 Tclin Aldose reductase (1404 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKR1A1 Tchem Aldehyde reductase (91 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SORD Tchem Sorbitol dehydrogenase (133 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSR Tclin Glutathione reductase (335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKR1B10 Tchem Aldo-keto reductase family 1 member B10 (300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB2 Tchem Nuclear factor NF-kappa-B complex (2307 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Akr1c21 Aldo-keto reductase family 1 member C21 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
INCHI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChi Key LXANPKRCLVQAOG-NSHDSACASA-N
Canonical SMILES C1COC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F
Isomeric SMILES C1COC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F
WGK Germany 3
PubChem CID 337359
Molecular Weight 236.2

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

References

1. Srivastava SK, Ramana KV, Bhatnagar A.  (2005)  Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options..  Endocr Rev,  26  (3): (380-92).  [PMID:15814847] [10.1021/op500134e]
2. Maccari R, Del Corso A, Giglio M, Moschini R, Mura U, Ottanà R.  (2011)  In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors..  Bioorg Med Chem Lett,  21  (1): (200-3).  [PMID:21129963] [10.1021/op500134e]
3. Sarges R, Bordner J, Dominy BW, Peterson MJ, Whipple EB.  (1985)  Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil..  J Med Chem,  28  (11): (1716-20).  [PMID:3934383] [10.1021/op500134e]
4. Jaspan J, Maselli R, Herold K, Bartkus C.  (1983)  Treatment of severely painful diabetic neuropathy with an aldose reductase inhibitor: relief of pain and improved somatic and autonomic nerve function..  Lancet,  (8353): (758-62).  [PMID:6137601] [10.1021/op500134e]
5. Greene DA, Lattimer SA.  (1984)  Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity..  Diabetes,  33  (8): (712-6).  [PMID:6086432] [10.1021/op500134e]
6. Young RJ, Ewing DJ, Clarke BF.  (1983)  A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy..  Diabetes,  32  (10): (938-42).  [PMID:6225686] [10.1021/op500134e]

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