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Sotorasib (AMG510) racemate - 97%, high purity , GTPase KRas inhibitor, CAS No.2252403-56-6, GTPase KRas inhibitor

Moligand™

≥97%

CAS#: 2252403-56-6
Formula: C₃₀H₃₀F₂N₆O₃
Molecular Weight: 560.59
PubChem CID: 137278711

Item Number

S414293

Grouped product items
SKU	Size	Availability	Price
S414293-2mg	2mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$29.90
S414293-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
S414293-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$76.90
S414293-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$155.90
S414293-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$249.90
S414293-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
S414293-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$799.90

Ras Inhibitors

View related series

KRAS Inhibitor

Basic Description

Synonyms	Sotorasib \| AMG-510 \| AMG510 \| 2296729-00-3 \| Lumakras \| 2252403-56-6 \| AMG-510 racemate \| AMG 510 \| Kras G12C inhibitor 9 \| sotorasibum \| 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimid
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	GTPase KRas inhibitor
Product Description	Information Sotorasib (AMG510) racemate Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. Targets KRAS G12Cv

Associated Targets(Human)

KRAS Tclin GTPase KRas (2 Activities)

Discover Target: KRAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NCI-H1975 (4994 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H358 (882 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MIA PaCa-2 (5949 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H23 (49055 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H1792 (313 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H2122 (340 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KRAS Tclin GTPase KRas (1864 Activities)

Discover Target: KRAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H1373 (66 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
INCHI	InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChi Key	NXQKSXLFSAEQCZ-SFHVURJKSA-N
Canonical SMILES	CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
Isomeric SMILES	C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
PubChem CID	137278711
Molecular Weight	560.59

PubChem CID

137278711

CAS Registry No.

2252403-56-6

Certificates

Certificate of Analysis(COA)

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11 results found

Lot Number	Certificate Type	Date	Item
L2321302	Certificate of Analysis	Dec 11, 2023	S414293
L2321304	Certificate of Analysis	Dec 11, 2023	S414293
L2321305	Certificate of Analysis	Dec 11, 2023	S414293
L2321307	Certificate of Analysis	Dec 11, 2023	S414293
L2321309	Certificate of Analysis	Dec 11, 2023	S414293
L2321374	Certificate of Analysis	Dec 11, 2023	S414293
L2321375	Certificate of Analysis	Dec 11, 2023	S414293
L2321378	Certificate of Analysis	Dec 11, 2023	S414293
L2321383	Certificate of Analysis	Dec 11, 2023	S414293
L2321384	Certificate of Analysis	Dec 11, 2023	S414293
L2321385	Certificate of Analysis	Dec 11, 2023	S414293

References

1. Hong DS, Fakih MG, Strickler JH, Desai J, Durm GA, Shapiro GI, Falchook GS, Price TJ, Sacher A, Denlinger CS et al.. (2020) KRAS^G12C Inhibition with Sotorasib in Advanced Solid Tumors.. N Engl J Med, 383 (13): (1207-1217). [PMID:32955176]
2. Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G et al.. (2020) Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors.. J Med Chem, 63 (1): (52-65). [PMID:31820981]

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Sotorasib (AMG510) racemate - 97%, high purity , GTPase KRas inhibitor, CAS No.2252403-56-6, GTPase KRas inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

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References

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