Grouped product items

SKU

Size

Availability

Price

Qty

S125985-1mg

1mg

In stock

$31.90

S125985-5mg

5mg

In stock

$92.90

S125985-25mg

25mg

In stock

$312.90

S125985-100mg

100mg

In stock

$789.90

Basic Description

Synonyms	Sotrastaurin\|425637-18-9\|AEB071\|Sotrastaurin (AEB071)\|AEB-071\|3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione\|3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione\|NVP-AEB071\|CHEBI:90531\|7I27
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Sotrastaurin, a first-in-class protein kinase C (PKC) inhibitor, is aiming to become the first oral treatment that inhibits T-cell activation since the introduction of calcineurin inhibitors. T-cell activation is an early step in autoimmune diseases such
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Protein kinase C (PKC) inhibitor

Product Properties

ALogP	2.6

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

Discover Target: CTH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK1 Tchem Cyclin-dependent kinase 1 0 Activities

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 0 Activities

Discover Target: ERBB4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHB6 Tchem Ephrin type-B receptor 6 0 Activities

Discover Target: EPHB6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DNAJA1 Tchem DnaJ homolog subfamily A member 1 0 Activities

Discover Target: DNAJA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK9 Tchem Cyclin-dependent kinase 9 0 Activities

Discover Target: CDK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDKL5 Tchem Cyclin-dependent kinase-like 5 0 Activities

Discover Target: CDKL5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

Discover Target: FLT4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

Discover Target: YES1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

Discover Target: FGFR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKACG Tchem cAMP-dependent protein kinase catalytic subunit gamma 0 Activities

Discover Target: PRKACG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

Discover Target: PLK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

Discover Target: PIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0 Activities

Discover Target: PIK3CG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

Discover Target: PDGFRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM2 Tchem Serine/threonine-protein kinase pim-2 1 Activities

Discover Target: PIM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CB Tchem Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 Activities

Discover Target: PIK3CB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM3 Tchem Serine/threonine-protein kinase pim-3 0 Activities

Discover Target: PIM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKG2 Tchem cGMP-dependent protein kinase 2 0 Activities

Discover Target: PRKG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCH Tchem Protein kinase C eta type 4 Activities

Discover Target: PRKCH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKD1 Tchem Serine/threonine-protein kinase D1 0 Activities

Discover Target: PRKD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATR Tchem Serine/threonine-protein kinase ATR 0 Activities

Discover Target: ATR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B 0 Activities

Discover Target: AURKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

Discover Target: AAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK2 Tclin Activated CDC42 kinase 1 0 Activities

Discover Target: TNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

Discover Target: AKT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

Discover Target: AKT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

Discover Target: AKT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

Discover Target: CLK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

Discover Target: CLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 0 Activities

Discover Target: MAP2K1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
INCHI	InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
InChi Key	OAVGBZOFDPFGPJ-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
Isomeric SMILES	CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
PubChem CID	10296883
Molecular Weight	438.49

Database links

PubChem CID	10296883
CAS Registry No.	425637-18-9
ChEMBL Ligand	CHEMBL565612
RCSB PDB Ligand	LW4

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
G2219935	Certificate of Analysis	May 15, 2024	S125985
G2219936	Certificate of Analysis	May 15, 2024	S125985
G2219937	Certificate of Analysis	May 15, 2024	S125985
G2220078	Certificate of Analysis	May 15, 2024	S125985

Chemical and Physical Properties

Solubility	DMSO 87 mg/mL Water <1 mg/mL Ethanol 2 mg/mL

Alternative Products

References

1. Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A et al.. (2009) Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.. J Med Chem, 52 (20): (6193-6). [PMID:19827831]

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Sotrastaurin - 98%, high purity , Protein kinase C (PKC) inhibitor, CAS No.425637-18-9, Protein kinase C (PKC) inhibitor

Basic Description

Product Properties

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

CDK1 Tchem Cyclin-dependent kinase 1 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 0 Activities

EPHB6 Tchem Ephrin type-B receptor 6 0 Activities

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

EGFR Tclin Epidermal growth factor receptor 0 Activities

DNAJA1 Tchem DnaJ homolog subfamily A member 1 0 Activities

CDK9 Tchem Cyclin-dependent kinase 9 0 Activities

CDKL5 Tchem Cyclin-dependent kinase-like 5 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

MET Tclin Hepatocyte growth factor receptor 0 Activities

IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

PRKACG Tchem cAMP-dependent protein kinase catalytic subunit gamma 0 Activities

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0 Activities

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

PIM2 Tchem Serine/threonine-protein kinase pim-2 1 Activities

PIK3CB Tchem Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 Activities

PIM3 Tchem Serine/threonine-protein kinase pim-3 0 Activities

PRKG2 Tchem cGMP-dependent protein kinase 2 0 Activities

PRKCH Tchem Protein kinase C eta type 4 Activities

PRKD1 Tchem Serine/threonine-protein kinase D1 0 Activities

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

ATR Tchem Serine/threonine-protein kinase ATR 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

AURKB Tchem Aurora kinase B 0 Activities

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

TNK2 Tclin Activated CDC42 kinase 1 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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References

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