sovesudil , CAS No.S613662, Inhibitor of Rho associated coiled-coil containing protein kinase 2

Item Number

S613662

Grouped product items
SKU	Size	Availability	Price	Qty
S613662-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S613662-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,711.90

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Basic Description

Synonyms	Sovesudil \| 1333400-14-8 \| Sovesudil [INN] \| PHP-201 \| Ama0076 \| C23O3R93BM \| PHP201 \| CHEMBL2440750 \| AMA-0076 \| propyl 3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]benzoate \| (1,1'-Biphenyl)-3-carboxylic acid, 2'-(aminomethyl)-5'-(((3-fluoro-4-pyridinyl)ami
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Rho associated coiled-coil containing protein kinase 2

Associated Targets(Human)

ROCK2 Tclin Rho-associated protein kinase 2 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK2 Tclin Rho-associated protein kinase 2 (6206 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	propyl 3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]benzoate
INCHI	InChI=1S/C23H22FN3O3/c1-2-10-30-23(29)17-5-3-4-15(11-17)19-12-16(6-7-18(19)13-25)22(28)27-21-8-9-26-14-20(21)24/h3-9,11-12,14H,2,10,13,25H2,1H3,(H,26,27,28)
InChi Key	PNWBYIFLWUCWKS-UHFFFAOYSA-N
Canonical SMILES	CCCOC(=O)c1cccc(c1)c1cc(ccc1CN)C(=O)Nc1ccncc1F
Isomeric SMILES	CCCOC(=O)C1=CC=CC(=C1)C2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3)F)CN
PubChem CID	68245749

PubChem CID

ChEMBL Ligand

BindingDB Ligand

References

1. Kast R, Schirok H, Figueroa-Pérez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hütter J et al.. (2007) Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.. Br J Pharmacol, 152 (7): (1070-80). [PMID:17934515]
2. Boland S, Defert O, Alen J, Bourin A, Castermans K, Kindt N, Boumans N, Panitti L, Van de Velde S, Stalmans I et al.. (2013) 3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors.. Bioorg Med Chem Lett, 23 (23): (6442-6). [PMID:24119557]

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Basic Description