SP-4206 , CAS No.S613665

Item Number
S613665
Grouped product items
SKUSizeAvailabilityPrice Qty
S613665-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90
S613665-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,561.90

Basic Description

Synonymscompound 13;SP4206
Specifications & PurityMoligand™
GradeMoligand™

Associated Targets(Human)

IL2 Tchem Interleukin-2 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IL2RA Tclin Interleukin-2 receptor alpha chain (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Il2 Interleukin-2 (29 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid
INCHI InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)/t21-/m1/s1
InChi Key VNZHOIDQBPFEJU-OAQYLSRUSA-N
Canonical SMILES CC(C[C@H](C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)c1ccc(c(c1Cl)Cl)OCc1ccc(o1)C(=O)O)N=C(N)N)C
Isomeric SMILES CC(C)C[C@H](C(=O)NCC(=O)N1CCC(CC1)C2=CC(=NN2C)C3=C(C(=C(C=C3)OCC4=CC=C(O4)C(=O)O)Cl)Cl)N=C(N)N
PubChem CID 5288251

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

References

1. Thanos CD, DeLano WL, Wells JA.  (2006)  Hot-spot mimicry of a cytokine receptor by a small molecule..  Proc Natl Acad Sci USA,  103  (42): (15422-7).  [PMID:17032757]
2. Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC.  (2003)  Discovery of a potent small molecule IL-2 inhibitor through fragment assembly..  J Am Chem Soc,  125  (13): (3714-5).  [PMID:12656598]
3. Thanos CD, Randal M, Wells JA.  (2003)  Potent small-molecule binding to a dynamic hot spot on IL-2..  J Am Chem Soc,  125  (50): (15280-1).  [PMID:14664558]
4. Arkin MR, Wells JA.  (2004)  Small-molecule inhibitors of protein-protein interactions: progressing towards the dream..  Nat Rev Drug Discov,  (4): (301-17).  [PMID:15060526]

Solution Calculators