Basic Description

Associated Targets(Human)

IL2 Tchem Interleukin-2 (3 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL2RA Tclin Interleukin-2 receptor alpha chain (2 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Il2 Interleukin-2 (29 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid
INCHI	InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)/t21-/m1/s1
InChi Key	VNZHOIDQBPFEJU-OAQYLSRUSA-N
Canonical SMILES	CC(C[C@H](C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)c1ccc(c(c1Cl)Cl)OCc1ccc(o1)C(=O)O)N=C(N)N)C
Isomeric SMILES	CC(C)C[C@H](C(=O)NCC(=O)N1CCC(CC1)C2=CC(=NN2C)C3=C(C(=C(C=C3)OCC4=CC=C(O4)C(=O)O)Cl)Cl)N=C(N)N
PubChem CID	5288251

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1. Thanos CD, DeLano WL, Wells JA. (2006) Hot-spot mimicry of a cytokine receptor by a small molecule.. Proc Natl Acad Sci USA, 103 (42): (15422-7). [PMID:17032757] [10.1021/op500134e]
2. Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.. J Am Chem Soc, 125 (13): (3714-5). [PMID:12656598] [10.1021/op500134e]
3. Thanos CD, Randal M, Wells JA. (2003) Potent small-molecule binding to a dynamic hot spot on IL-2.. J Am Chem Soc, 125 (50): (15280-1). [PMID:14664558] [10.1021/op500134e]
4. Arkin MR, Wells JA. (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.. Nat Rev Drug Discov, 3 (4): (301-17). [PMID:15060526] [10.1021/op500134e]

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SKU	Size	Availability	Price	Qty
S613665-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
S613665-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,561.90