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SP600125 - ≥98%, high purity , CAS No.129-56-6, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

7 Citations
Item Number
S125267
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S125267-25mg
25mg
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$26.90
S125267-50mg
50mg
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$56.90
S125267-100mg
100mg
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$88.90
S125267-500mg
500mg
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$177.90
S125267-1g
1g
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$320.90
S125267-5g
5g
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JNK inhibitor

View related series
Apoptosis Autophagy Ferroptosis JNK MAPK/ERK Pathway mitogen-activated protein kinase 10 Inhibitor mitogen-activated protein kinase 8 Inhibitor mitogen-activated protein kinase 9 Inhibitor

Basic Description

SynonymsHMS1362F07 | KBioGR_000406 | Anthra[1-9-cd]pyrazol-6(2H)-one | SDCCGSBI-0050458.P003 | WLN: T C66651A P IV OMNJ | Pyrazolanthrone | Pyrazoleanthrone | HMS3295M01 | 2,6-dihydrodibenzo[cd,g]indazol-6-one | JMC517015 Compound 2 | Bio1_001313 | NCGC00015958-0
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsSP600125 is selective inhibitor of c-Jun N-terminal kinase (JNK). SP600125 competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 ＞ 10 μM). Active in vivo. Shown
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3

Associated Targets(Human)

MAPK10 Tchem Mitogen-activated protein kinase 10 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPK8 Tchem Mitogen-activated protein kinase 8 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPK9 Tchem Mitogen-activated protein kinase 9 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
INCHI InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChi Key ACPOUJIDANTYHO-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
Isomeric SMILES C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
PubChem CID 8515
Molecular Weight 220.233

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
L1805123Certificate of AnalysisMay 14, 2024 S125267
L1805121Certificate of AnalysisMay 14, 2024 S125267
F2209263Certificate of AnalysisMar 20, 2024 S125267
F2209277Certificate of AnalysisMar 20, 2024 S125267
F2209285Certificate of AnalysisMar 20, 2024 S125267
A2125110Certificate of AnalysisNov 16, 2022 S125267

Chemical and Physical Properties

SolubilityDMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
SensitivityHeat Sensitive
Melt Point(°C)283°C

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang.  (2023)  Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.  ENVIRONMENTAL TOXICOLOGY,  38  (7): (1756-1767).  [PMID:37070943] [10.1002/tox.23805]
2. Niu Ting, Wei Zhiying, Fu Jiao, Chen Shu, Wang Ru, Wang Yuya, Zheng Ruihe.  (2023)  Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway.  Frontiers in Pharmacology,  13    [PMID:36686679] [10.3389/fphar.2022.1080412]
3. Xing Ying, Liu Yang, Qi Zhong, Liu Zhengrong, Wang Xin, Zhang Hongyi.  (2021)  LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  26  (1): (1-16).  [PMID:34837962] [10.1186/s11658-021-00295-4]
4. Bai Yu, Du Qiang, Zhang Le, Li Ling, Wang Nana, Wu Bo, Li Ping, Li Ling.  (2021)  Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells.  Frontiers in Endocrinology,  12  (597).  [PMID:34163433] [10.3389/fendo.2021.635321]
5. Zhaohui Shi, Min Xu, Xiaodong Chen, Jian Wang, Tianfeng Zhao, Dingjun Zha.  (2021)  The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells.  EXPERIMENTAL AND MOLECULAR PATHOLOGY,  118  (104591).  [PMID:33285209] [10.1016/j.yexmp.2020.104591]
6. Tian Xusheng, Zhang Yukun, Li Han, Li Yunfeng, Wang Ning, Zhang Wei, Ma Boyan.  (2020)  Palmatine ameliorates high fat diet induced impaired glucose tolerance.  BIOLOGICAL RESEARCH,  53  (1): (1-12).  [PMID:32928312] [10.1186/s40659-020-00308-0]
7. Kang An, Yuehan Zhang, Yingjiao Liu, Shengxi Yan, Zhaowei Hou, Meng Cao, Guangkuo Liu, Congcong Dong, Juncha Gao, Gaifang Liu.  (2020)  Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.  ONCOLOGY REPORTS,  44  (3): (1116-1126).  [PMID:32705225] [10.3892/or.2020.7675]

References

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43. Niu Ting, Wei Zhiying, Fu Jiao, Chen Shu, Wang Ru, Wang Yuya, Zheng Ruihe.  (2023)  Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway.  Frontiers in Pharmacology,  13    [PMID:36686679] [10.3389/fphar.2022.1080412]
44. Xing Ying, Liu Yang, Qi Zhong, Liu Zhengrong, Wang Xin, Zhang Hongyi.  (2021)  LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  26  (1): (1-16).  [PMID:34837962] [10.1186/s11658-021-00295-4]
45. Bai Yu, Du Qiang, Zhang Le, Li Ling, Wang Nana, Wu Bo, Li Ping, Li Ling.  (2021)  Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells.  Frontiers in Endocrinology,  12  (597).  [PMID:34163433] [10.3389/fendo.2021.635321]
46. Zhaohui Shi, Min Xu, Xiaodong Chen, Jian Wang, Tianfeng Zhao, Dingjun Zha.  (2021)  The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells.  EXPERIMENTAL AND MOLECULAR PATHOLOGY,  118  (104591).  [PMID:33285209] [10.1016/j.yexmp.2020.104591]
47. Tian Xusheng, Zhang Yukun, Li Han, Li Yunfeng, Wang Ning, Zhang Wei, Ma Boyan.  (2020)  Palmatine ameliorates high fat diet induced impaired glucose tolerance.  BIOLOGICAL RESEARCH,  53  (1): (1-12).  [PMID:32928312] [10.1186/s40659-020-00308-0]
48. Kang An, Yuehan Zhang, Yingjiao Liu, Shengxi Yan, Zhaowei Hou, Meng Cao, Guangkuo Liu, Congcong Dong, Juncha Gao, Gaifang Liu.  (2020)  Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.  ONCOLOGY REPORTS,  44  (3): (1116-1126).  [PMID:32705225] [10.3892/or.2020.7675]

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