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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S125267-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $26.90 | |
S125267-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $56.90 | |
S125267-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $88.90 | |
S125267-500mg | 500mg | In stock | $177.90 | |
S125267-1g | 1g | In stock | $320.90 | |
S125267-5g | 5g | In stock | $1,441.90 |
JNK inhibitor
Synonyms | 129-56-6|1,9-Pyrazoloanthrone|SP600125|Pyrazolanthrone|Dibenzo[cd,g]indazol-6(2H)-one|Pyrazoleanthrone|SP 600125|Anthra[1,9-cd]pyrazol-6(2H)-one|SP-600125|JNK Inhibitor II|Anthra-1,9-pyrazol-6-none|ANTHRA(1,9-cd)PYRAZOL-6(2H)-ONE|C.I. 70300|2H-Dibenzo[cd, |
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Specifications & Purity | ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9 |
Product Description | SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one |
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INCHI | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
InChi Key | ACPOUJIDANTYHO-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O |
Isomeric SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O |
PubChem CID | 8515 |
Molecular Weight | 220.233 |
CAS Registry No. | 129-56-6 |
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Wikipedia | 1,9-Pyrazoloanthrone |
PubChem CID | 8515 |
RCSB PDB Ligand | 537 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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L1805123 | Certificate of Analysis | May 14, 2024 | S125267 |
L1805121 | Certificate of Analysis | May 14, 2024 | S125267 |
F2209263 | Certificate of Analysis | Mar 20, 2024 | S125267 |
F2209277 | Certificate of Analysis | Mar 20, 2024 | S125267 |
F2209285 | Certificate of Analysis | Mar 20, 2024 | S125267 |
A2125110 | Certificate of Analysis | Nov 16, 2022 | S125267 |
Solubility | DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 283°C |
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