Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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S129372-1g | 1g | In stock | $25.90 | |
S129372-5g | 5g | In stock | $112.90 | |
S129372-25g | 25g | In stock | $507.90 | |
S129372-100g | 100g | In stock | $1,828.90 |
Bacterial DNA gyrase (topoisomerase iV) inhibitor, fluoroquniolone antibiotic
Synonyms | Esparfloxacino | AC-11574 | GTPL10860 | Sparfloxacin & RU 40555 | SR-05000001521-1 | HMS2090N19 | Sparfloxacin, Antibiotic for Culture Media Use Only | 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarb |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Sparfloxacin is a fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects. Spa |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.. |
ALogP | 0.1 |
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IUPAC Name | 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid |
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INCHI | InChI=1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+ |
InChi Key | DZZWHBIBMUVIIW-DTORHVGOSA-N |
Canonical SMILES | CC1CN(CC(N1)C)C2=C(C(=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)N)F |
Isomeric SMILES | C[C@@H]1CN(C[C@@H](N1)C)C2=C(C(=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)N)F |
WGK Germany | 2 |
RTECS | VB1986500 |
PubChem CID | 60464 |
Molecular Weight | 392.4 |
Beilstein | 9170271 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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J2218063 | Certificate of Analysis | Aug 14, 2024 | S129372 |
J2218180 | Certificate of Analysis | Aug 14, 2024 | S129372 |
J2218199 | Certificate of Analysis | Aug 14, 2024 | S129372 |
J2218273 | Certificate of Analysis | Aug 14, 2024 | S129372 |
I2102331 | Certificate of Analysis | Jun 16, 2023 | S129372 |
I2102332 | Certificate of Analysis | Jun 16, 2023 | S129372 |
Solubility | Soluble in water (<1 mg/ml), 100% ethanol, chloroform, methanol, and DMSO (9 mg/ml). |
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Sensitivity | Light sensitive |
Flash Point(°F) | 230°F |
Flash Point(°C) | >110°C |
Boil Point(°C) | 640℃ |
Melt Point(°C) | 265°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | VB1986500 |
1. Wang Jiarui, Feng Juanjuan, Sun Min, Lian Yujing, Wang Minglin, Qiao Luqin. (2023) Sulfonic acid-functionalized covalent organic frameworks as the coating for stir bar sorptive extraction of fluoroquinolones in milk samples. MICROCHIMICA ACTA, 190 (1): (1-9). [PMID:36469152] |
2. Jia-Yu Zeng, Yu-Qi Liang, Yan-Ni Wu, Xiao-Yi Wu, Jia-Ping Lai, Hui Sun. (2022) Synthesis and application of novel N, Si-carbon dots for the ratiometric fluorescent monitoring of the antibiotic balofloxacin in tablets and serum. RSC Advances, 12 (45): (29585-29594). [PMID:36320748] |
3. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:] |
4. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319] |
5. Liang Yu-Qi, Wu Xiao-Yi, Zeng Jia-Yu, Wu Yan-Ni, Lai Jia-Ping, Sun Hui. (2022) A novel fluorescence ratio probe based on dual-emission carbon dots for highly selective and sensitive detection of chlortetracycline and cell imaging. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (9): (3043-3055). [PMID:35195741] |
6. Jin Yuting, Yan Rongfang, Wang Shuo, Wang Xianghong, Zhang Xuemei, Tang Yiwei. (2022) Dipeptide nanoparticle and aptamer-based hybrid fluorescence platform for enrofloxacin determination. MICROCHIMICA ACTA, 189 (3): (1-8). [PMID:35147788] |
7. Zhiwen Li, Jiyue Zhang, Qiyao Sun, Wenwen Shi, Tingxian Tao, Yingqiang Fu. (2022) Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe. NEW JOURNAL OF CHEMISTRY, 46 (9): (4226-4232). [PMID:] |
1. Domagala JM, Bridges AJ, Culbertson TP, Gambino L, Hagen SE, Karrick G, Porter K, Sanchez JP, Sesnie JA, Spense FG et al.. (1991) Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.. J Med Chem, 34 (3): (1142-54). [PMID:1848296] |
2. Psaty BM. (2008) Clinical trial design and selected drug safety issues for antibiotics used to treat community-acquired pneumonia.. Clin Infect Dis, 47 Suppl 3 (3): (S176-9). [PMID:18986285] |
3. Ohtsuka M, Kikuchi K, Shimizu K, Takahashi N, Ono Y, Sasaki T, Hiramatsu K. (2009) Emergence of quinolone-resistant Bordetella pertussis in Japan.. Antimicrob Agents Chemother, 53 (7): (3147-9). [PMID:19414571] |
4. Wang Jiarui, Feng Juanjuan, Sun Min, Lian Yujing, Wang Minglin, Qiao Luqin. (2023) Sulfonic acid-functionalized covalent organic frameworks as the coating for stir bar sorptive extraction of fluoroquinolones in milk samples. MICROCHIMICA ACTA, 190 (1): (1-9). [PMID:36469152] |
5. Jia-Yu Zeng, Yu-Qi Liang, Yan-Ni Wu, Xiao-Yi Wu, Jia-Ping Lai, Hui Sun. (2022) Synthesis and application of novel N, Si-carbon dots for the ratiometric fluorescent monitoring of the antibiotic balofloxacin in tablets and serum. RSC Advances, 12 (45): (29585-29594). [PMID:36320748] |
6. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:] |
7. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319] |
8. Liang Yu-Qi, Wu Xiao-Yi, Zeng Jia-Yu, Wu Yan-Ni, Lai Jia-Ping, Sun Hui. (2022) A novel fluorescence ratio probe based on dual-emission carbon dots for highly selective and sensitive detection of chlortetracycline and cell imaging. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (9): (3043-3055). [PMID:35195741] |
9. Jin Yuting, Yan Rongfang, Wang Shuo, Wang Xianghong, Zhang Xuemei, Tang Yiwei. (2022) Dipeptide nanoparticle and aptamer-based hybrid fluorescence platform for enrofloxacin determination. MICROCHIMICA ACTA, 189 (3): (1-8). [PMID:35147788] |
10. Zhiwen Li, Jiyue Zhang, Qiyao Sun, Wenwen Shi, Tingxian Tao, Yingqiang Fu. (2022) Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe. NEW JOURNAL OF CHEMISTRY, 46 (9): (4226-4232). [PMID:] |