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Spautin-1 - 10mM in DMSO, high purity , CAS No.1262888-28-7
Cell-permeable USP10 and USP13 inhibitor
Basic Description Synonyms CS-4616 | A889470 | CS1815 | MBCQ derivative C43 | NCGC00263555-05 | deoxy-ATP, 2'-deoxyadenosine triphosphate, Deoxyadenosine 5'-triphosphate | EN300-93027 | P2613 | Spautin-1 | CCG-267171 | 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine | HMS3871D13 | EN Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in va Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Product Application：
Spautin-1 has been used as an autophagy inhibitor:
to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model;
to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin;
to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine INCHI InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20) InChi Key AWIVHRPYFSSVOG-UHFFFAOYSA-N Canonical SMILES C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F Isomeric SMILES C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F WGK Germany 3 PubChem CID 51037431 Molecular Weight 271.26
Chemical and Physical Properties Sensitivity heat & air sensitive Melt Point(°C) 211 °C
Safety and Hazards(GHS) Pictogram(s) GHS05 , GHS07 Signal Danger Hazard Statements H302: Harmful if swallowed
H318: Causes serious eye damage
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
WGK Germany 3
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