Basic Description

Synonyms	Spectinomycin dihydrochloride pentahydrate \| 22189-32-8 \| Trobicin \| Spectinomycin hydrochloride \| Spectogard \| Spectinomycin HCl \| Spectinomycin hydrochloride hydrate \| Spectam \| U 18,400AE \| U-18,409AE \| Espectinomicina dihydrochloride pentahydrate \| Spectinomycin hcl pentah
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	An aminocyclcitol antibiotic . Active against Gram-positive and Gram-negative bacteria. Binds the 30S ribosome subunit and interrupts protein synthesis by interfering with peptidyl tRNA translocation.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr and to inhibit bacterial protein synthesis at the level of peptidy tRNA translocation

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one;pentahydrate;dihydrochloride
INCHI	InChI=1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;21H;51H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
InChi Key	DCHJOVNPPSBWHK-UXXUFHFZSA-N
Canonical SMILES	CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O.O.O.O.O.O.Cl.Cl
Isomeric SMILES	C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O.O.O.O.O.O.Cl.Cl
WGK Germany	2
Alternate CAS	1695-77-8；21736-83-4
PubChem CID	30971
Molecular Weight	495.35

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Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P284:[In case of inadequate ventilation] Wear respiratory protection. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	2
Merck Index	8739

1. Zhongnan Huang, Zhenglian Li, Yao Chen, Luyao Xu, Qianlong Xie, Haohua Deng, Wei Chen, Huaping Peng. (2021) Regulating Valence States of Gold Nanocluster as a New Strategy for the Ultrasensitive Electrochemiluminescence Detection of Kanamycin. ANALYTICAL CHEMISTRY, 93 (10): (4635–4640). [PMID:33661613]

1. Zhongnan Huang, Zhenglian Li, Yao Chen, Luyao Xu, Qianlong Xie, Haohua Deng, Wei Chen, Huaping Peng. (2021) Regulating Valence States of Gold Nanocluster as a New Strategy for the Ultrasensitive Electrochemiluminescence Detection of Kanamycin. ANALYTICAL CHEMISTRY, 93 (10): (4635–4640). [PMID:33661613]

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