Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S113079-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $43.90 | |
S113079-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $171.90 | |
S113079-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $685.90 |
Synonyms | spermine | 71-44-3 | musculamine | neuridine | gerontine | Spermin | 4,9-Diaza-1,12-dodecanediamine | N,N'-Bis(3-aminopropyl)-1,4-butanediamine | Spermine, puriss | Diaminopropyltetramethylenediamine | N,N'-Bis(3-aminopropyl)butane-1,4-diamine | 1,4-Butanediamine, N,N'-bis(3-a |
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Specifications & Purity | Moligand™, for cell culture, ≥98%(GC) |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | for cell culture, Moligand™ |
Action Type | AGONIST, CHANNEL BLOCKER |
Mechanism of action | Agonist of CaS receptor;Channel blocker of K ir2.1;Channel blocker of K ir2.3;Agonist of Retinoic acid receptor-α;Agonist of Retinoic acid receptor-β;Agonist of Retinoic acid receptor-γ;Channel blocker of TRPM4;Channel blocker of TRPM5;Channel blocker of |
Product Description | Spermine is a biogenic polyamine formed from spermidine and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. Spermine is a GluR inhibitor. |
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IUPAC Name | N,N'-bis(3-aminopropyl)butane-1,4-diamine |
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INCHI | InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 |
InChi Key | PFNFFQXMRSDOHW-UHFFFAOYSA-N |
Canonical SMILES | C(CCNCCCN)CNCCCN |
Isomeric SMILES | C(CCNCCCN)CNCCCN |
WGK Germany | 3 |
RTECS | EJ7175000 |
PubChem CID | 1103 |
UN Number | 3259 |
Molecular Weight | 202.34 |
Beilstein | 1750791 |
PubChem CID | 2126 |
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ChEMBL Ligand | CHEMBL69367 |
CAS Registry No. | 71-44-3 |
BindingDB Ligand | 50052414 |
NURSA Ligand | 10.1621/ZA9Z1YGHZP |
RCSB PDB Ligand | EQN |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2207122 | Certificate of Analysis | Jun 20, 2024 | S113079 |
L2319172 | Certificate of Analysis | Dec 12, 2023 | S113079 |
L2319473 | Certificate of Analysis | Dec 12, 2023 | S113079 |
A2221090 | Certificate of Analysis | Nov 14, 2023 | S113079 |
A2221091 | Certificate of Analysis | Nov 14, 2023 | S113079 |
I2405036 | Certificate of Analysis | Jul 10, 2023 | S113079 |
J2111007 | Certificate of Analysis | Jul 10, 2023 | S113079 |
J2111066 | Certificate of Analysis | Jul 10, 2023 | S113079 |
I2109145 | Certificate of Analysis | Jun 15, 2023 | S113079 |
C1925160 | Certificate of Analysis | Nov 11, 2022 | S113079 |
I2207118 | Certificate of Analysis | Jul 28, 2022 | S113079 |
I2207119 | Certificate of Analysis | Jul 28, 2022 | S113079 |
I2207120 | Certificate of Analysis | Jul 28, 2022 | S113079 |
I2207121 | Certificate of Analysis | Jul 19, 2022 | S113079 |
G2031089 | Certificate of Analysis | Jun 14, 2022 | S113079 |
A2221093 | Certificate of Analysis | Dec 29, 2021 | S113079 |
Solubility | Soluble in chloroform, methanol, water, and lower alcohols. Insoluble in ether, benzene, and petroleum ether. |
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Sensitivity | Moisture ,air sensitive |
Flash Point(°F) | 110 °C |
Flash Point(°C) | 110°C |
Boil Point(°C) | 150 °C/5 mmHg |
Melt Point(°C) | 28-30°C |
Pictogram(s) | GHS05 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H411:Toxic to aquatic life with long lasting effects H317:May cause an allergic skin reaction H226:Flammable liquid and vapor H304:May be fatal if swallowed and enters airways |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use ... to extinguish. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P264:Wash hands [and …] thoroughly after handling. P403+P235:Store in a well-ventilated place. Keep cool. P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment. P331:Do NOT induce vomiting. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
WGK Germany | 3 |
RTECS | EJ7175000 |
1. Wan-Xue Li, Jing-Xiang Chen, Chuan-Chuan Zhang, Min-Shi Luo, Wen-Qing Zhang. (2024) Functional analysis of Ornithine decarboxylase in manipulating the wing dimorphism in Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). JOURNAL OF INSECT PHYSIOLOGY, 152 (19): (104587). [PMID:38043786] |
2. Junjun Wang, Yue Tang, Jia Zheng, Zhengmin Xie, Jianli Zhou, Yuangen Wu. (2024) DNAzyme-based and smartphone-assisted colorimetric biosensor for ultrasensitive and highly selective detection of histamine in meats. FOOD CHEMISTRY, 435 (13): (137526). [PMID:37742463] |
3. Zekun Shi, Yongning Wu, Xue Zhang, Yanyan Gao, Luqin Qiao, Qin Hou, Minglin Wang. (2023) Highly sensitive and selective colorimetric and fluorescent dual-readout assay for the analysis of spermine, spermidine and cysteine. DYES AND PIGMENTS, 220 (111659). [PMID:] |
4. Yeye Hu, Ziliang He, Ji Zhang, Chaohua Zhang, Yanting Wang, Wei Zhang, Fenglun Zhang, Weiming Zhang, Fenglin Gu, Weicheng Hu. (2023) Effect of Piper nigrum essential oil in dextran sulfate sodium (DSS)-induced colitis and its potential mechanisms. PHYTOMEDICINE, 119 (155024). [PMID:37597364] |
5. Bobo Hu, Nana Zhang, Huihui Li, Chong Sun. (2021) A non-enzymatic Electrochemical Sensor Based on rGO-PPy for Rapid and Sensitive Determination of Histamine in Meat. International Journal of Electrochemical Science, 16 (210550). [PMID:37095754] |
6. Chunxia Zhang, Rongrong Liu, Xueping Kong, Hongwei Li, Dahai Yu, Xuexun Fang, Lixin Wu, Yuqing Wu. (2023) Adaptive Responses of a Peroxidase-like Polyoxometalate-Based Tri-Assembly to Bacterial Microenvironment (BME) Significantly Improved the Anti-Bacterial Effects. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (10): (8858). [PMID:37240203] |
7. Nuo Duan, Kexin Ren, Mingqian Song, Xinyue Zhang, Zhouping Wang, Fei Jia, Shijia Wu. (2023) A dual-donor FRET based aptamer sensor for simultaneous determination of histamine and tyramine in fishes. MICROCHEMICAL JOURNAL, 191 (108801). [PMID:] |
8. Si Lin, Hou Juying, Lv Wei, Hou Qin, Xu Zhixiang, Ai Shiyun. (2023) An intelligent fluorescence platform based on lignocellulose components and fluorescein for food freshness monitoring. Biomass Conversion and Biorefinery, (1-11). [PMID:] |
9. Wenyang Zhang, Da-Wen Sun, Ji Ma, Anjun Qin, Ben Zhong Tang. (2023) A ratiometric fluorescent tag based on dual-emissive hydrophobic carbon dots for in-situ monitoring of seafood freshness. ANALYTICA CHIMICA ACTA, 1250 (340931). [PMID:36898807] |
10. Wang Tingting, Chen Yihui, Hou Chunyan, Qiao Xiaoqiang. (2023) PEG-modified halloysite as a hydrophilic interaction and cation exchange mixed-mode sorbent for solid-phase extraction of biogenic amines in fish samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4265-4275). [PMID:36422664] |
11. Guoqing Wang, Xinyue Meng, Peiyan Wang, Xinping Wang, Gaoli Liu, Dong-An Wang, Changjiang Fan. (2022) A catechol bioadhesive for rapid hemostasis and healing of traumatic internal organs and major arteries. BIOMATERIALS, 291 (121908). [PMID:36384085] |
12. Yuan-Fu Ding, Jianwen Wei, Xingping Quan, Wenting Gu, Long Xi, Ying Zheng, Yonghua Zhao, Jingwei Luo, Shengke Li, Greta S.P. Mok, Ruibing Wang. (2022) Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis. CARBOHYDRATE POLYMERS, 296 (119968). [PMID:36088007] |
13. Jianfeng Yan, Quanbin Fu, Shikai Zhang, Yu Liu, Xianbao Shi, Juying Hou, Junling Duan, Shiyun Ai. (2022) A sensitive ratiometric fluorescent sensor based on carbon dots and CdTe quantum dots for visual detection of biogenic amines in food samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 282 (121706). [PMID:35933782] |
14. Liu Dehong, Shi Hongjie, Chen Guanglin, Zhang Xu, Gu Tingyue, Zhu Minglong, Tan Wensong. (2022) Strategies for anti-oxidative stress and anti-acid stress in bioleaching of LiCoO2 using an acidophilic microbial consortium. EXTREMOPHILES, 26 (2): (1-16). [PMID:35767155] |
15. Lancheng Wang, Mingjie Xu, Huimin Zhou, Kun Yan, Shiqi Duan, Dandan Xue, Youmei Wang, Bin Di, Chi Hu. (2022) Teaching PCR for Simultaneous Sensing of Gene Transcription and Downstream Metabolites by Cucurbit[8]uril-Mediated Intervention of Polymerase Activity. ANALYTICAL CHEMISTRY, 94 (24): (8715–8723). [PMID:35671188] |
16. Yujuan Qin, Pengcheng Huang, Fang-Ying Wu. (2022) Histamine-responsive dye-incorporated carbon dots for visual monitoring of food spoilage. SENSORS AND ACTUATORS B-CHEMICAL, 365 (131911). [PMID:] |
17. Qianqian Zhang, Jianwei Bao, Tijie Duan, Minxing Hu, Yuting He, Junwei Wang, Rongfeng Hu, Jihui Tang. (2022) Nanomicelle-Microsphere Composite as a Drug Carrier to Improve Lung-Targeting Specificity for Lung Cancer. Pharmaceutics, 14 (3): (510). [PMID:35335884] |
18. Xu Xu, Jiaxin Gao, Di Cao, Xiang Li, Xin Zhao, Shuang Yue, Lei Zhang. (2022) Designed 3D N-doped magnetic porous carbon spheres for sensitive monitoring of biogenic amine by simultaneous microwave-assisted derivatization and magnetic-solid phase extraction. JOURNAL OF CHROMATOGRAPHY A, 1667 (462882). [PMID:35149412] |
19. Xinxiu Ma, Jingran Bi, Xinyu Li, Gongliang Zhang, Hongshun Hao, Hongman Hou. (2021) Contribution of Microorganisms to Biogenic Amine Accumulation during Fish Sauce Fermentation and Screening of Novel Starters. Foods, 10 (11): (2572). [PMID:34828853] |
1. Charton J, Deprez-Poulain R, Hennuyer N, Tailleux A, Staels B, Deprez B. (2009) Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.. Bioorg Med Chem Lett, 19 (2): (489-92). [PMID:19058965] |
2. Wang W, Yang J, Liu H, Lu D, Chen X, Zenonos Z, Campos LS, Rad R, Guo G, Zhang S et al.. (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.. Proc Natl Acad Sci USA, 108 (45): (18283-8). [PMID:21990348] |
3. Wan-Xue Li, Jing-Xiang Chen, Chuan-Chuan Zhang, Min-Shi Luo, Wen-Qing Zhang. (2024) Functional analysis of Ornithine decarboxylase in manipulating the wing dimorphism in Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). JOURNAL OF INSECT PHYSIOLOGY, 152 (19): (104587). [PMID:38043786] |
4. Junjun Wang, Yue Tang, Jia Zheng, Zhengmin Xie, Jianli Zhou, Yuangen Wu. (2024) DNAzyme-based and smartphone-assisted colorimetric biosensor for ultrasensitive and highly selective detection of histamine in meats. FOOD CHEMISTRY, 435 (13): (137526). [PMID:37742463] |
5. Zekun Shi, Yongning Wu, Xue Zhang, Yanyan Gao, Luqin Qiao, Qin Hou, Minglin Wang. (2023) Highly sensitive and selective colorimetric and fluorescent dual-readout assay for the analysis of spermine, spermidine and cysteine. DYES AND PIGMENTS, 220 (111659). [PMID:] |
6. Yeye Hu, Ziliang He, Ji Zhang, Chaohua Zhang, Yanting Wang, Wei Zhang, Fenglun Zhang, Weiming Zhang, Fenglin Gu, Weicheng Hu. (2023) Effect of Piper nigrum essential oil in dextran sulfate sodium (DSS)-induced colitis and its potential mechanisms. PHYTOMEDICINE, 119 (155024). [PMID:37597364] |
7. Bobo Hu, Nana Zhang, Huihui Li, Chong Sun. (2021) A non-enzymatic Electrochemical Sensor Based on rGO-PPy for Rapid and Sensitive Determination of Histamine in Meat. International Journal of Electrochemical Science, 16 (210550). [PMID:37095754] |
8. Chunxia Zhang, Rongrong Liu, Xueping Kong, Hongwei Li, Dahai Yu, Xuexun Fang, Lixin Wu, Yuqing Wu. (2023) Adaptive Responses of a Peroxidase-like Polyoxometalate-Based Tri-Assembly to Bacterial Microenvironment (BME) Significantly Improved the Anti-Bacterial Effects. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (10): (8858). [PMID:37240203] |
9. Nuo Duan, Kexin Ren, Mingqian Song, Xinyue Zhang, Zhouping Wang, Fei Jia, Shijia Wu. (2023) A dual-donor FRET based aptamer sensor for simultaneous determination of histamine and tyramine in fishes. MICROCHEMICAL JOURNAL, 191 (108801). [PMID:] |
10. Si Lin, Hou Juying, Lv Wei, Hou Qin, Xu Zhixiang, Ai Shiyun. (2023) An intelligent fluorescence platform based on lignocellulose components and fluorescein for food freshness monitoring. Biomass Conversion and Biorefinery, (1-11). [PMID:] |
11. Wenyang Zhang, Da-Wen Sun, Ji Ma, Anjun Qin, Ben Zhong Tang. (2023) A ratiometric fluorescent tag based on dual-emissive hydrophobic carbon dots for in-situ monitoring of seafood freshness. ANALYTICA CHIMICA ACTA, 1250 (340931). [PMID:36898807] |
12. Wang Tingting, Chen Yihui, Hou Chunyan, Qiao Xiaoqiang. (2023) PEG-modified halloysite as a hydrophilic interaction and cation exchange mixed-mode sorbent for solid-phase extraction of biogenic amines in fish samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4265-4275). [PMID:36422664] |
13. Guoqing Wang, Xinyue Meng, Peiyan Wang, Xinping Wang, Gaoli Liu, Dong-An Wang, Changjiang Fan. (2022) A catechol bioadhesive for rapid hemostasis and healing of traumatic internal organs and major arteries. BIOMATERIALS, 291 (121908). [PMID:36384085] |
14. Yuan-Fu Ding, Jianwen Wei, Xingping Quan, Wenting Gu, Long Xi, Ying Zheng, Yonghua Zhao, Jingwei Luo, Shengke Li, Greta S.P. Mok, Ruibing Wang. (2022) Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis. CARBOHYDRATE POLYMERS, 296 (119968). [PMID:36088007] |
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