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SPH3127 , Renin inhibitor, CAS No.S613671, Renin inhibitor

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SPH3127 , Renin inhibitor, CAS No.S613671, Renin inhibitor

Moligand™

PubChem CID: 117877477

Item Number

S613671

Grouped product items
SKU	Size	Availability	Price	Qty
S613671-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S613671-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90

View related series

renin Inhibitor

Basic Description

Synonyms	SPH3127 \| SPH-3127 \| 1399849-02-5 \| C2M78A9V6Z \| CHEMBL4110551 \| SCHEMBL16471589 \| GTPL12196 \| BDBM212579 \| GLXC-26423 \| compound 18 [PMID: 35939295] \| HY-151111 \| CS-0567609 \| US9278944, 270 \| Carbamic acid, N-(3-(3-((1R)-1-(cyclopropyl((2R)-2-morpholinylcarbonyl)amino)ethyl)-6-m
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Renin inhibitor

Associated Targets(Human)

REN Tclin Renin (1 Activities)

Discover Target: REN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

REN Tclin Renin (5251 Activities)

Discover Target: REN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cynomolgus monkey (4946 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

INCHI	InChI=1S/C22H32N6O4/c1-14-5-8-17-19(26-27(20(17)25-14)11-4-9-24-22(30)31-3)15(2)28(16-6-7-16)21(29)18-13-23-10-12-32-18/h5,8,15-16,18,23H,4,6-7,9-13H2,1-3H3,(H,24,30)/t15-,18-/m1/s1
InChi Key	GRTDDIZIUSADLD-CRAIPNDOSA-N
Canonical SMILES	COC(=O)NCCCn1nc([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)c2ccc(C)nc12
Isomeric SMILES	CC1=NC2=C(C=C1)C(=NN2CCCNC(=O)OC)[C@@H](C)N(C3CC3)C(=O)[C@H]4CNCCO4
PubChem CID	117877477

Database links

PubChem CID	117877477
ChEMBL Ligand	CHEMBL4110551
BindingDB Ligand	212579

Certificates

Certificate of Analysis(COA)

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References

1. Iijima D, Sugama H, Takahashi Y, Hirai M, Togashi Y, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T et al.. (2022) Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.. J Med Chem, 65 (16): (10882-10897). [PMID:35939295]

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