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SPI-112 - 10mM in DMSO, high purity , CAS No.1051387-90-6
Basic Description Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms SPI-112 is a not cell permeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, PTPN11) with IC50 of 1 μM in cell-free assay. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
SPI-112 SPI-112 is a not cell permeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, PTPN11) with IC50 of 1 μM in cell-free assay.
Targets
SHP-2 (Cell-free assay) 1 μM
Product Properties ALogP 2.859 HBD Count 3 Rotatable Bond 7
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 3-[[5-[(4-fluorophenyl)methylsulfamoyl]-2-hydroxy-1H-indol-3-yl]diazenyl]benzoic acid INCHI InChI=1S/C22H17FN4O5S/c23-15-6-4-13(5-7-15)12-24-33(31,32)17-8-9-19-18(11-17)20(21(28)25-19)27-26-16-3-1-2-14(10-16)22(29)30/h1-11,24-25,28H,12H2,(H,29,30) InChi Key ZSXZSNNAEVDPNL-UHFFFAOYSA-N Canonical SMILES C1=CC(=CC(=C1)N=NC2=C(NC3=C2C=C(C=C3)S(=O)(=O)NCC4=CC=C(C=C4)F)O)C(=O)O Isomeric SMILES C1=CC(=CC(=C1)N=NC2=C(NC3=C2C=C(C=C3)S(=O)(=O)NCC4=CC=C(C=C4)F)O)C(=O)O PubChem CID 135924028 Molecular Weight 468.46
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 94 DMSO(mM) Max Solubility 200.657473423558 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P302+P352: IF ON SKIN: wash with plenty of water.
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