Spiperone hydrochloride - ≥98%, high purity , CAS No.2022-29-9

  • ≥98%
Item Number
S275020
Grouped product items
SKUSizeAvailabilityPrice Qty
S275020-10mg
10mg
In stock
$162.90
S275020-50mg
50mg
In stock
$733.90

5-HT and D 2 -like receptor antagonist

Basic Description

SynonymsSpiperone (hydrochloride) | SR-01000000261-3 | 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride | SR-01000000261 | C23H26FN3O2.HCl | SCHEMBL466892 | NCGC00261754-01 | AKOS024458725 | CCG-222373 | LP01069 | Spirope
Specifications & Purity≥98%
Biochemical and Physiological Mechanisms5-HT and D 2 -like receptor antagonist. (IC 50 values are 1.6 and 15 nM at 5-HT 2 and 5-HT 1C receptors, respectively. K i values are 0.06 ( D 2 ), 0.6 (D 3 ), 0.08 (D 4 ), ~ 350 (D 1 ) and ~ 3500 nM (D 5 )). Potently enhances intracellular Ca 2+ levels.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. The product can be stored for up to 12 months.

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride
INCHI InChI=1S/C23H26FN3O2.ClH/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20;/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29);1H
InChi Key QUIKMLCZZMOBLH-UHFFFAOYSA-N
Canonical SMILES C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(=O)C4=CC=C(C=C4)F.Cl
Isomeric SMILES C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(=O)C4=CC=C(C=C4)F.Cl
PubChem CID 11957687
Molecular Weight 431.94

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
A2310184Certificate of AnalysisOct 24, 2023 S275020
A2310162Certificate of AnalysisOct 18, 2023 S275020

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM
SensitivityMoisture sensitive

Related Documents

References

1. Odaka H et al..  (2014)  Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity..  PLoS One,  (6): (e99271).  [PMID:24914776]
2. Ward AH et al..  (2017)  Intravitreally-administered dopamine D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews..  Vis Neurosci,  34  (E003).  [PMID:28304244]

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