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Spironolactone - ≥97 %, high purity , Mineralocorticoid receptor antagonist, CAS No.52-01-7, Mineralocorticoid receptor antagonist

Specifications & Purity: ≥97 %

CAS#: 52-01-7
Formula: C₂₄H₃₂O₄S
Molecular Weight: 416.57
EC Number: 200-133-6
MDL number: MFCD00082250
PubChem CID: 5833

Item Number

S303875

Grouped product items
SKU	Size	Availability	Price
S303875-250mg	250mg	In stock	$55.90
S303875-1g	1g	In stock	$138.90
S303875-5g	5g	In stock	$412.90
S303875-25g	25g	In stock	$1,374.90

Mineralocorticoid receptor antagonist

View related series

Mineralocorticoid receptor Antagonist

Basic Description

Synonyms	spironolactone\|52-01-7\|Aldactone\|Spirolactone\|Verospirone\|Euteberol\|Verospiron\|Spirolang\|Acelat\|Spironocompren\|Melarcon\|Spiresis\|Spiridon\|Spiroctan\|Uractone\|Urusonin\|Alderon\|Spirone\|Xenalon\|Dira\|Spiro-Tablinen\|Aldactone A\|Spironolactone A\|spironolattone\|S
Specifications & Purity	≥97 %
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	ANTAGONIST
Mechanism of action	Mineralocorticoid receptor antagonist

Associated Targets

NR3C1 Tclin Glucocorticoid receptor 1 Activities

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C2 Tclin Mineralocorticoid receptor 13 Activities

Discover Target: NR3C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor 1 Activities

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
INCHI	InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChi Key	LXMSZDCAJNLERA-ZHYRCANASA-N
Canonical SMILES	CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C
Isomeric SMILES	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
Alternate CAS	52-01-7
PubChem CID	5833
NSC Number	150399
MeSH Entry Terms	Aldactone;Aldactone A;Aquareduct;Ct, Spiro Von;duraspiron;Espironolactona Alter;Espironolactona Mundogen;Flumach;Frumikal;Jenaspiron;Novo Spiroton;Novo-Spiroton;NovoSpiroton;Practon;SC 9420;SC-9420;SC9420;Spiractin;Spiro L.U.T.;spiro von ct;Spirobeta;Spir
Molecular Weight	416.57

DrugBank Ligand

PubChem CID

ChEMBL Ligand

BindingDB Ligand

Wikipedia

CAS Registry No.

NURSA Ligand

RCSB PDB Ligand

PEP

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
F2116023	Certificate of Analysis	Apr 02, 2024	S303875
D2110375	Certificate of Analysis	Feb 23, 2024	S303875
I2207046	Certificate of Analysis	Jun 23, 2022	S303875
I2207048	Certificate of Analysis	Jun 23, 2022	S303875
I2207049	Certificate of Analysis	Jun 23, 2022	S303875
L2319092	Certificate of Analysis	Jun 23, 2022	S303875
F2227039	Certificate of Analysis	Mar 09, 2021	S303875
G2201704	Certificate of Analysis	Mar 09, 2021	S303875

Solubility

Soluble in chloroform and methanol. Slightly soluble in water.

Melt Point(°C)

207-208 °C (lit.)

Pictogram(s)

GHS08,GHS07

Signal

Danger

Hazard Statements

H351,H373,H302,H312,H332,H360

Precautionary Statements

P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P362+P364,P330,P203,P301+P317,P318,P317,P319

References

1. Ding H et al.. (2021) Anti-stress effects of combined block of glucocorticoid and mineralocorticoid receptors in the paraventricular nucleus of the hypothalamus.. Br J Pharmacol, 178 (18): (3696-3707). [PMID:33908038]
2. Zhang B et al.. (2020) Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling.. J Neuroinflammation, 17 (318). [PMID:33100225]
3. Zhang B et al.. (2021) The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors.. Front Pharmacol, 12 (713715). [PMID:34381366]

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Spironolactone - ≥97 %, high purity , Mineralocorticoid receptor antagonist, CAS No.52-01-7, Mineralocorticoid receptor antagonist

Basic Description

Product Properties

Associated Targets

NR3C1 Tclin Glucocorticoid receptor 1 Activities

NR3C2 Tclin Mineralocorticoid receptor 13 Activities

AR Tclin Androgen receptor 1 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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