The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
SPP 86 - ≥98%(HPLC), high purity , CAS No.1357349-91-7
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated act Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-(2-phenylethynyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine INCHI InChI=1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19) InChi Key JQOIRTDBHMDWMT-UHFFFAOYSA-N Canonical SMILES CC(C)N1C2=NC=NC(=C2C(=N1)C#CC3=CC=CC=C3)N Isomeric SMILES CC(C)N1C2=NC=NC(=C2C(=N1)C#CC3=CC=CC=C3)N PubChem CID 66549796 Molecular Weight 277.32
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 27.73, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.55, Max Conc. mM: 20
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P301+P312+P330: IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
RIDADR NONHforallmodesoftransport
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
B2215362