SPRi 3 - ≥98%(HPLC), high purity , CAS No.1292285-54-1, Inhibitor of sepiapterin reductase

Item Number

S287577

Grouped product items
SKU	Size	Availability	Price
S287577-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$39.90
S287577-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$110.90
S287577-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$166.90
S287577-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$365.90
S287577-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$658.90

Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells

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Basic Description

Synonyms	SPR inhibitor 3;SPRi3
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent sepiapterin reductase (SPR) inhibitor (IC50= 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+T cells. Suppresses proliferation of human effector CD4+T cells following stimulation. Reduces SPR acti
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of sepiapterin reductase
Product Description	SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.

Names and Identifiers

IUPAC Name	N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
INCHI	InChI=1S/C14H18N2O3/c1-9-11(5-6-15-14(18)8-19-2)12-7-10(17)3-4-13(12)16-9/h3-4,7,16-17H,5-6,8H2,1-2H3,(H,15,18)
InChi Key	YBXBWBBVLXZQBJ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(N1)C=CC(=C2)O)CCNC(=O)COC
Isomeric SMILES	CC1=C(C2=C(N1)C=CC(=C2)O)CCNC(=O)COC
PubChem CID	52911386
Molecular Weight	262.30

References

1. Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M et al.. (2015) Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.. Neuron, 86 (6): (1393-406). [PMID:26087165] [10.1021/op500134e]
2. Haruki H, Hovius R, Pedersen MG, Johnsson K. (2016) Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid.. J Biol Chem, 291 (2): (652-7). [PMID:26565027] [10.1021/op500134e]

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Basic Description