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SPRi3 , CAS No.S613680, Inhibitor of sepiapterin reductase

Item Number

S613680

Grouped product items
SKU	Size	Availability	Price	Qty
S613680-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S613680-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	example 23 [WO2011047156];SPR inhibitor 3
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of sepiapterin reductase

SPR Tchem Sepiapterin reductase (4 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
INCHI	InChI=1S/C14H18N2O3/c1-9-11(5-6-15-14(18)8-19-2)12-7-10(17)3-4-13(12)16-9/h3-4,7,16-17H,5-6,8H2,1-2H3,(H,15,18)
InChi Key	YBXBWBBVLXZQBJ-UHFFFAOYSA-N
Canonical SMILES	COCC(=O)NCCc1c(C)[nH]c2c1cc(O)cc2
Isomeric SMILES	CC1=C(C2=C(N1)C=CC(=C2)O)CCNC(=O)COC
PubChem CID	52911386

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1. Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M et al.. (2015) Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.. Neuron, 86 (6): (1393-406). [PMID:26087165] [10.1021/op500134e]
2. Haruki H, Hovius R, Pedersen MG, Johnsson K. (2016) Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid.. J Biol Chem, 291 (2): (652-7). [PMID:26565027] [10.1021/op500134e]

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