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SQ-29548 - ≥98%, high purity , CAS No.98672-91-4, Antagonist of TP receptor

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SQ-29548 - ≥98%, high purity , CAS No.98672-91-4, Antagonist of TP receptor

Moligand™

≥98%

CAS#: 98672-91-4
Formula: C₂₁H₂₉N₃O₄
Molecular Weight: 387.47
PubChem CID: 5311448

Item Number

S336934

Grouped product items
SKU	Size	Availability	Price	Qty
S336934-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$454.90
S336934-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,095.90

a potent and selective thromboxane A2 receptor antagonist

View related series

GPCR/G Protein Prostaglandin Receptor TP receptor Antagonist

Basic Description

Synonyms	SQ 29548 \| (Z)-7-((1S,2R,3R,4R)-3-((2-(Phenylcarbamoyl)hydrazineyl)methyl)-7-oxabicyclo[2.2.1]heptan-2-yl)hept-5-enoic acid \| 5-Heptenoic acid, 7-((1S,2R,3R,4R)-3-((2- ((phenylamino)carbonyl)hydrazino)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-, (5Z)- \| HY
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of TP receptor
Note	Chemical can be stored as supplied for 1 year at -20° C.
Product Description	SQ-29548 is a compound that reversibly and competitively acts as a TXA2R (thromboxane A\|2\|/prostraglandin endoperoxide receptor) antagonist. Ischemic studies show that SQ 29548 significantly rescues myocardial tissue and Canine postischemic cerebral hypoperfusion studies report that SQ-29548 does not help improve postischemic cerebral hypoperfusion. SQ-29548 has been shown to bind and inhibit the thromboxane A2/prostaglandin endoperoxide receptor more potently than ONO 3708, BM 13.17, and 13-APA .

Product Properties

Ki Data	[3H]-U-46619 binding to human platelet membranes: Ki= 7.9 nM

Associated Targets(Human)

TBXA2R Tclin Thromboxane A2 receptor (1 Activities)

Discover Target: TBXA2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(Z)-7-[(1S,2R,3R,4R)-3-[[2-(phenylcarbamoyl)hydrazinyl]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
INCHI	InChI=1S/C21H29N3O4/c25-20(26)11-7-2-1-6-10-16-17(19-13-12-18(16)28-19)14-22-24-21(27)23-15-8-4-3-5-9-15/h1,3-6,8-9,16-19,22H,2,7,10-14H2,(H,25,26)(H2,23,24,27)/b6-1-/t16-,17+,18+,19-/m1/s1
InChi Key	RJNDVCNWVBWHLY-YVUOLYODSA-N
Canonical SMILES	C1CC2C(C(C1O2)CC=CCCCC(=O)O)CNNC(=O)NC3=CC=CC=C3
Isomeric SMILES	C1C[C@@H]2[C@H]([C@H]([C@H]1O2)C/C=C\CCCC(=O)O)CNNC(=O)NC3=CC=CC=C3
WGK Germany	3
PubChem CID	5311448
Molecular Weight	387.47

Database links

PubChem CID	6437074
CAS Registry No.	98672-91-4
GPCRdb Ligand	SQ-29548

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Soluble in ethanol, methanol, acetonitrile, PBS pH 7.2, DMSO, dimethyl formamide , and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (4.7 mg/mL). Insoluble in water.
Refractive Index	n20D1.58
Specific Rotation[α]	α22/D +19.8°, c = 1.4 in methanol(lit.)

Safety and Hazards(GHS)

WGK Germany	3

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