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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | squalene | 111-02-4 | Spinacene | trans-Squalene | Supraene | All-trans-Squalene | 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene | Nikko Squalane EX | Spinacen | Super Squalene | 7683-64-9 | (E,E,E,E)-Squalene | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa- |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Squalene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high densit |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | Squalene is a biosynthetic precursor for all steroids that is cytoprotective to normal cells exposed to carcinogens and antitumor agents |
Associated Targets(Human)
SQLE Tchem Squalene monooxygenase (0 Activities)
KMT2A Tchem Histone-lysine N-methyltransferase 2A (0 Activities)
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MCF7 (126967 Activities)
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NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
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HeLa (62764 Activities)
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MDA-MB-231 (73002 Activities)
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KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
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Associated Targets(non-human)
ERG1 Squalene monooxygenase (20 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Staphylococcus aureus (210822 Activities)
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Mycobacterium tuberculosis (203094 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Entamoeba histolytica (2676 Activities)
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Names and Identifiers
| IUPAC Name | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene |
|---|---|
| INCHI | InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ |
| InChi Key | YYGNTYWPHWGJRM-AAJYLUCBSA-N |
| Canonical SMILES | CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C |
| Isomeric SMILES | CC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)/C)/C)C |
| WGK Germany | 2 |
| RTECS | XB6010000 |
| PubChem CID | 638072 |
| Molecular Weight | 410.72 |
| Beilstein | 1728919 |
| Reaxy-Rn | 1728920 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Sensitivity | air sensitive;light sensitive |
|---|---|
| Refractive Index | 1.4965 |
| Flash Point(°F) | 230 °F |
| Flash Point(°C) | 200℃ |
| Boil Point(°C) | 252 °C |
| Melt Point(°C) | -75°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H304:May be fatal if swallowed and enters airways |
| Precautionary Statements | P405:Store locked up. P501:Dispose of contents/container to ... P331:Do NOT induce vomiting. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
| WGK Germany | 2 |
| RTECS | XB6010000 |
| Reaxy-Rn | 1728920 |
Related Documents
Citations of This Product
| 1. Yue Qun, Meng Jie, Qiu Yue, Yin Miaomiao, Zhang Liwen, Zhou Weiping, An Zhiqiang, Liu Zihe, Yuan Qipeng, Sun Wentao, Li Chun, Zhao Huimin, Molnár István, Xu Yuquan, Shi Shuobo. (2023) A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi. Nature Communications, 14 (1): (1-10). [PMID:37460548] |
| 2. Zhongju Ji, Baolian Fan, Yidu Chen, Jingyang Yue, Jiabo Chen, Rongrong Zhang, Yi Tong, Zhongqiu Liu, Jincai Liang, Lixin Duan. (2023) Functional characterization of triterpene synthases in Cibotium barometz. Synthetic and Systems Biotechnology, 8 (437). [PMID:37416896] |
| 3. Qimeng Zhang, Qifan Zhao, Bingbing Zhu, Rong Chen, Yating Zhou, Xiaopeng Pei, Hua Zhou, Huiyong An, Ying Tan, Chengshui Chen. (2023) Acetalized starch-based nanoparticles stabilized acid-sensitive Pickering emulsion as a potential antitumor drug carrier. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 244 (125393). [PMID:37331543] |
| 4. Nouman Ali Shah, Rui Hong, Xue Yang, Shi-Shu Huang, Rizwan M. Gul, Yuwei Liu, Lingli Li, Jia-Zhuang Xu, Ka Li, Zhong-Ming Li. (2023) Synergy stabilization of vitamin E and D-sorbitol on crosslinked ultrahigh molecular weight polyethylene for artificial joint under in-vitro clinically relevant accelerated aging. POLYMER DEGRADATION AND STABILITY, 214 (110382). [PMID:] |
| 5. Feng Wang, Chao Li, Haohao Wang, Lu Yu, Fuming Zhang, Robert J. Linhardt. (2023) Amphiphilic O(Phe-r-Glu) oligopeptides randomly polymerized via papain exhibiting a pH-insensitive emulsification property. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 664 (131141). [PMID:] |
| 6. Anning Liu, Huijuan Jing, Xiaojing Du, Chaoyang Ma, Hongxin Wang. (2022) Efficient Ultrasonic-assisted Aqueous Enzymatic Method for Pecan Nut Kernel Oil Extraction with Quality Analysis. Journal of Oleo Science, [PMID:36464287] |
| 7. Luo Mingfang, Lv Yijie, Luo Xunrong, Ren Qingfa, Sun Zhenbo, Li Tianping, Wang Ailing, Liu Yan, Yang Caixia, Li Xianglin. (2022) Developing Smart Nanoparticles Responsive to the Tumor Micro-Environment for Enhanced Synergism of Thermo-Chemotherapy With PA/MR Bimodal Imaging. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35265592] |
References
| 1. Yue Qun, Meng Jie, Qiu Yue, Yin Miaomiao, Zhang Liwen, Zhou Weiping, An Zhiqiang, Liu Zihe, Yuan Qipeng, Sun Wentao, Li Chun, Zhao Huimin, Molnár István, Xu Yuquan, Shi Shuobo. (2023) A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi. Nature Communications, 14 (1): (1-10). [PMID:37460548] |
| 2. Zhongju Ji, Baolian Fan, Yidu Chen, Jingyang Yue, Jiabo Chen, Rongrong Zhang, Yi Tong, Zhongqiu Liu, Jincai Liang, Lixin Duan. (2023) Functional characterization of triterpene synthases in Cibotium barometz. Synthetic and Systems Biotechnology, 8 (437). [PMID:37416896] |
| 3. Qimeng Zhang, Qifan Zhao, Bingbing Zhu, Rong Chen, Yating Zhou, Xiaopeng Pei, Hua Zhou, Huiyong An, Ying Tan, Chengshui Chen. (2023) Acetalized starch-based nanoparticles stabilized acid-sensitive Pickering emulsion as a potential antitumor drug carrier. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 244 (125393). [PMID:37331543] |
| 4. Nouman Ali Shah, Rui Hong, Xue Yang, Shi-Shu Huang, Rizwan M. Gul, Yuwei Liu, Lingli Li, Jia-Zhuang Xu, Ka Li, Zhong-Ming Li. (2023) Synergy stabilization of vitamin E and D-sorbitol on crosslinked ultrahigh molecular weight polyethylene for artificial joint under in-vitro clinically relevant accelerated aging. POLYMER DEGRADATION AND STABILITY, 214 (110382). [PMID:] |
| 5. Feng Wang, Chao Li, Haohao Wang, Lu Yu, Fuming Zhang, Robert J. Linhardt. (2023) Amphiphilic O(Phe-r-Glu) oligopeptides randomly polymerized via papain exhibiting a pH-insensitive emulsification property. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 664 (131141). [PMID:] |
| 6. Anning Liu, Huijuan Jing, Xiaojing Du, Chaoyang Ma, Hongxin Wang. (2022) Efficient Ultrasonic-assisted Aqueous Enzymatic Method for Pecan Nut Kernel Oil Extraction with Quality Analysis. Journal of Oleo Science, [PMID:36464287] |
| 7. Luo Mingfang, Lv Yijie, Luo Xunrong, Ren Qingfa, Sun Zhenbo, Li Tianping, Wang Ailing, Liu Yan, Yang Caixia, Li Xianglin. (2022) Developing Smart Nanoparticles Responsive to the Tumor Micro-Environment for Enhanced Synergism of Thermo-Chemotherapy With PA/MR Bimodal Imaging. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35265592] |