Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Basic Description
| Synonyms | squalene | 111-02-4 | Spinacene | trans-Squalene | Supraene | All-trans-Squalene | 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene | Nikko Squalane EX | Spinacen | Super Squalene | 7683-64-9 | (E,E,E,E)-Squalene | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa- |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Squalene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high densit |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | Squalene is a biosynthetic precursor for all steroids that is cytoprotective to normal cells exposed to carcinogens and antitumor agents |
Associated Targets(Human)
MCF7 (126967 Activities)
NCI-H460 (60772 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SF-268 (49410 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HeLa (62764 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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MDA-MB-231 (73002 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Associated Targets(non-human)
ERG1 Squalene monooxygenase (20 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Staphylococcus aureus (210822 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mycobacterium tuberculosis (203094 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Entamoeba histolytica (2676 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene |
|---|---|
| INCHI | InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ |
| InChi Key | YYGNTYWPHWGJRM-AAJYLUCBSA-N |
| Canonical SMILES | CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C |
| Isomeric SMILES | CC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)/C)/C)C |
| WGK Germany | 2 |
| RTECS | XB6010000 |
| PubChem CID | 638072 |
| Molecular Weight | 410.72 |
| Beilstein | 1728919 |
| Reaxy-Rn | 1728920 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Sensitivity | air sensitive;light sensitive |
|---|---|
| Refractive Index | 1.4965 |
| Flash Point(°F) | 230 °F |
| Flash Point(°C) | 200℃ |
| Boil Point(°C) | 252 °C |
| Melt Point(°C) | -75°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H304:May be fatal if swallowed and enters airways |
| Precautionary Statements | P405:Store locked up. P501:Dispose of contents/container to ... P331:Do NOT induce vomiting. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
| WGK Germany | 2 |
| RTECS | XB6010000 |
| Reaxy-Rn | 1728920 |
Related Documents
Citations of This Product
| 1. Yue Qun, Meng Jie, Qiu Yue, Yin Miaomiao, Zhang Liwen, Zhou Weiping, An Zhiqiang, Liu Zihe, Yuan Qipeng, Sun Wentao, Li Chun, Zhao Huimin, Molnár István, Xu Yuquan, Shi Shuobo. (2023) A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi. Nature Communications, 14 (1): (1-10). [PMID:37460548] [10.1038/s41467-023-40027-0] |
| 2. Zhongju Ji, Baolian Fan, Yidu Chen, Jingyang Yue, Jiabo Chen, Rongrong Zhang, Yi Tong, Zhongqiu Liu, Jincai Liang, Lixin Duan. (2023) Functional characterization of triterpene synthases in Cibotium barometz. Synthetic and Systems Biotechnology, 8 (437). [PMID:37416896] [10.1016/j.synbio.2023.06.005] |
| 3. Qimeng Zhang, Qifan Zhao, Bingbing Zhu, Rong Chen, Yating Zhou, Xiaopeng Pei, Hua Zhou, Huiyong An, Ying Tan, Chengshui Chen. (2023) Acetalized starch-based nanoparticles stabilized acid-sensitive Pickering emulsion as a potential antitumor drug carrier. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 244 (125393). [PMID:37331543] [10.1016/j.ijbiomac.2023.125393] |
| 4. Nouman Ali Shah, Rui Hong, Xue Yang, Shi-Shu Huang, Rizwan M. Gul, Yuwei Liu, Lingli Li, Jia-Zhuang Xu, Ka Li, Zhong-Ming Li. (2023) Synergy stabilization of vitamin E and D-sorbitol on crosslinked ultrahigh molecular weight polyethylene for artificial joint under in-vitro clinically relevant accelerated aging. POLYMER DEGRADATION AND STABILITY, 214 (110382). [PMID:] [10.1016/j.polymdegradstab.2023.110382] |
| 5. Feng Wang, Chao Li, Haohao Wang, Lu Yu, Fuming Zhang, Robert J. Linhardt. (2023) Amphiphilic O(Phe-r-Glu) oligopeptides randomly polymerized via papain exhibiting a pH-insensitive emulsification property. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 664 (131141). [PMID:] [10.1016/j.colsurfa.2023.131141] |
| 6. Anning Liu, Huijuan Jing, Xiaojing Du, Chaoyang Ma, Hongxin Wang. (2022) Efficient Ultrasonic-assisted Aqueous Enzymatic Method for Pecan Nut Kernel Oil Extraction with Quality Analysis. Journal of Oleo Science, [PMID:36464287] [10.5650/jos.ess22119] |
| 7. Luo Mingfang, Lv Yijie, Luo Xunrong, Ren Qingfa, Sun Zhenbo, Li Tianping, Wang Ailing, Liu Yan, Yang Caixia, Li Xianglin. (2022) Developing Smart Nanoparticles Responsive to the Tumor Micro-Environment for Enhanced Synergism of Thermo-Chemotherapy With PA/MR Bimodal Imaging. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35265592] [10.3389/fbioe.2022.799610] |
| 8. Zihan Xu, Shanshan Liu, Mingyue Shen, Jianhua Xie, Jun Yang. (2022) Evaluation of trans fatty acids, carbonyl compounds and bioactive minor components in commercial linseed oils. FOOD CHEMISTRY, 369 (130930). [PMID:34469834] [10.1016/j.foodchem.2021.130930] |
| 9. Chi Zhang, Zhinan Fan, Hao Zhan, Hong Zhou, Rongliang Ma, Li-Juan Fan. (2021) Fluorescent Cationic Conjugated Polymer-Based Adaptive Developing Strategy for Both Sebaceous and Blood Fingerprints. ACS Applied Materials & Interfaces, 13 (23): (27419–27429). [PMID:34080426] [10.1021/acsami.1c04741] |
| 10. Liu Shanshan, Hu Huiyu, Yu Yanpeng, Zhao Jiahui, Liu Lichun, Zhao Shanshan, Xie Jianhua, Li Chang, Shen Mingyue. (2021) Simultaneous Determination of Tocopherols, Phytosterols, and Squalene in Vegetable Oils by High Performance Liquid Chromatography-Tandem Mass Spectrometry. Food Analytical Methods, 14 (8): (1567-1576). [PMID:] [10.1007/s12161-021-01987-5] |
| 11. Pingping Zhou, Yi Du, Nannan Xu, Chunlei Yue, Lidan Ye. (2020) Improved linalool production in Saccharomyces cerevisiae by combining directed evolution of linalool synthase and overexpression of the complete mevalonate pathway. BIOCHEMICAL ENGINEERING JOURNAL, 161 (107655). [PMID:] [10.1016/j.bej.2020.107655] |
| 12. Tian Li, Guo-Song Liu, Wei Zhou, Min Jiang, Yu-Hong Ren, Xin-Yi Tao, Min Liu, Ming Zhao, Feng-Qing Wang, Bei Gao, Dong-Zhi Wei. (2020) Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (7): (2132–2138). [PMID:31989819] [10.1021/acs.jafc.9b07419] |
| 13. Dan Zhou, Qinlong Shi, Jiangbo Pan, Min Liu, Yi Long, Fahuan Ge. (2019) Effectively improve the quality of camellia oil by the combination of supercritical fluid extraction and molecular distillation (SFE-MD). LWT-FOOD SCIENCE AND TECHNOLOGY, 110 (175). [PMID:] [10.1016/j.lwt.2019.04.075] |
| 14. Jian-Yuan Yang, Jing Li, Mei Wang, Xian-Guo Zou, Bin Peng, Yu-Long Yin, Ze-Yuan Deng. (2019) A Novel Aqueous Extraction for Camellia Oil by Emulsified Oil: A Frozen/Thawed Method. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 121 (4): (1800431). [PMID:] [10.1002/ejlt.201800431] |
| 15. Ming Zhao, Shui-Ling Wang, Xin-Yi Tao, Guo-Ling Zhao, Yu-Hong Ren, Feng-Qing Wang, Dong-Zhi Wei. (2019) Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans. JOURNAL OF BIOTECHNOLOGY, 289 (93). [PMID:30481545] [10.1016/j.jbiotec.2018.11.017] |
| 16. Haiyuan Liu, Shu Han, Liping Xie, Jie Pan, Wei Zhang, Guihua Gong, Youjia Hu. (2017) Overexpression of key enzymes of the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for improving squalene production in Escherichia coli. AFRICAN JOURNAL OF BIOTECHNOLOGY, 16 (50): (2307-2316). [PMID:38147025] [10.5897/AJB2017.16235] |
| 17. H. Xiao, Z. Yao, Q. Peng, F. Ni, Y. Sun, C.X. Zhang, Z.X. Zhong. (2016) Extraction of squalene from camellia oil by silver ion complexation. SEPARATION AND PURIFICATION TECHNOLOGY, 169 (196). [PMID:] [10.1016/j.seppur.2016.05.041] |
References
| 1. Yue Qun, Meng Jie, Qiu Yue, Yin Miaomiao, Zhang Liwen, Zhou Weiping, An Zhiqiang, Liu Zihe, Yuan Qipeng, Sun Wentao, Li Chun, Zhao Huimin, Molnár István, Xu Yuquan, Shi Shuobo. (2023) A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi. Nature Communications, 14 (1): (1-10). [PMID:37460548] [10.1038/s41467-023-40027-0] |
| 2. Zhongju Ji, Baolian Fan, Yidu Chen, Jingyang Yue, Jiabo Chen, Rongrong Zhang, Yi Tong, Zhongqiu Liu, Jincai Liang, Lixin Duan. (2023) Functional characterization of triterpene synthases in Cibotium barometz. Synthetic and Systems Biotechnology, 8 (437). [PMID:37416896] [10.1016/j.synbio.2023.06.005] |
| 3. Qimeng Zhang, Qifan Zhao, Bingbing Zhu, Rong Chen, Yating Zhou, Xiaopeng Pei, Hua Zhou, Huiyong An, Ying Tan, Chengshui Chen. (2023) Acetalized starch-based nanoparticles stabilized acid-sensitive Pickering emulsion as a potential antitumor drug carrier. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 244 (125393). [PMID:37331543] [10.1016/j.ijbiomac.2023.125393] |
| 4. Nouman Ali Shah, Rui Hong, Xue Yang, Shi-Shu Huang, Rizwan M. Gul, Yuwei Liu, Lingli Li, Jia-Zhuang Xu, Ka Li, Zhong-Ming Li. (2023) Synergy stabilization of vitamin E and D-sorbitol on crosslinked ultrahigh molecular weight polyethylene for artificial joint under in-vitro clinically relevant accelerated aging. POLYMER DEGRADATION AND STABILITY, 214 (110382). [PMID:] [10.1016/j.polymdegradstab.2023.110382] |
| 5. Feng Wang, Chao Li, Haohao Wang, Lu Yu, Fuming Zhang, Robert J. Linhardt. (2023) Amphiphilic O(Phe-r-Glu) oligopeptides randomly polymerized via papain exhibiting a pH-insensitive emulsification property. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 664 (131141). [PMID:] [10.1016/j.colsurfa.2023.131141] |
| 6. Anning Liu, Huijuan Jing, Xiaojing Du, Chaoyang Ma, Hongxin Wang. (2022) Efficient Ultrasonic-assisted Aqueous Enzymatic Method for Pecan Nut Kernel Oil Extraction with Quality Analysis. Journal of Oleo Science, [PMID:36464287] [10.5650/jos.ess22119] |
| 7. Luo Mingfang, Lv Yijie, Luo Xunrong, Ren Qingfa, Sun Zhenbo, Li Tianping, Wang Ailing, Liu Yan, Yang Caixia, Li Xianglin. (2022) Developing Smart Nanoparticles Responsive to the Tumor Micro-Environment for Enhanced Synergism of Thermo-Chemotherapy With PA/MR Bimodal Imaging. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35265592] [10.3389/fbioe.2022.799610] |
| 8. Zihan Xu, Shanshan Liu, Mingyue Shen, Jianhua Xie, Jun Yang. (2022) Evaluation of trans fatty acids, carbonyl compounds and bioactive minor components in commercial linseed oils. FOOD CHEMISTRY, 369 (130930). [PMID:34469834] [10.1016/j.foodchem.2021.130930] |
| 9. Chi Zhang, Zhinan Fan, Hao Zhan, Hong Zhou, Rongliang Ma, Li-Juan Fan. (2021) Fluorescent Cationic Conjugated Polymer-Based Adaptive Developing Strategy for Both Sebaceous and Blood Fingerprints. ACS Applied Materials & Interfaces, 13 (23): (27419–27429). [PMID:34080426] [10.1021/acsami.1c04741] |
| 10. Liu Shanshan, Hu Huiyu, Yu Yanpeng, Zhao Jiahui, Liu Lichun, Zhao Shanshan, Xie Jianhua, Li Chang, Shen Mingyue. (2021) Simultaneous Determination of Tocopherols, Phytosterols, and Squalene in Vegetable Oils by High Performance Liquid Chromatography-Tandem Mass Spectrometry. Food Analytical Methods, 14 (8): (1567-1576). [PMID:] [10.1007/s12161-021-01987-5] |
| 11. Pingping Zhou, Yi Du, Nannan Xu, Chunlei Yue, Lidan Ye. (2020) Improved linalool production in Saccharomyces cerevisiae by combining directed evolution of linalool synthase and overexpression of the complete mevalonate pathway. BIOCHEMICAL ENGINEERING JOURNAL, 161 (107655). [PMID:] [10.1016/j.bej.2020.107655] |
| 12. Tian Li, Guo-Song Liu, Wei Zhou, Min Jiang, Yu-Hong Ren, Xin-Yi Tao, Min Liu, Ming Zhao, Feng-Qing Wang, Bei Gao, Dong-Zhi Wei. (2020) Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (7): (2132–2138). [PMID:31989819] [10.1021/acs.jafc.9b07419] |
| 13. Dan Zhou, Qinlong Shi, Jiangbo Pan, Min Liu, Yi Long, Fahuan Ge. (2019) Effectively improve the quality of camellia oil by the combination of supercritical fluid extraction and molecular distillation (SFE-MD). LWT-FOOD SCIENCE AND TECHNOLOGY, 110 (175). [PMID:] [10.1016/j.lwt.2019.04.075] |
| 14. Jian-Yuan Yang, Jing Li, Mei Wang, Xian-Guo Zou, Bin Peng, Yu-Long Yin, Ze-Yuan Deng. (2019) A Novel Aqueous Extraction for Camellia Oil by Emulsified Oil: A Frozen/Thawed Method. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 121 (4): (1800431). [PMID:] [10.1002/ejlt.201800431] |
| 15. Ming Zhao, Shui-Ling Wang, Xin-Yi Tao, Guo-Ling Zhao, Yu-Hong Ren, Feng-Qing Wang, Dong-Zhi Wei. (2019) Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans. JOURNAL OF BIOTECHNOLOGY, 289 (93). [PMID:30481545] [10.1016/j.jbiotec.2018.11.017] |
| 16. Haiyuan Liu, Shu Han, Liping Xie, Jie Pan, Wei Zhang, Guihua Gong, Youjia Hu. (2017) Overexpression of key enzymes of the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for improving squalene production in Escherichia coli. AFRICAN JOURNAL OF BIOTECHNOLOGY, 16 (50): (2307-2316). [PMID:38147025] [10.5897/AJB2017.16235] |
| 17. H. Xiao, Z. Yao, Q. Peng, F. Ni, Y. Sun, C.X. Zhang, Z.X. Zhong. (2016) Extraction of squalene from camellia oil by silver ion complexation. SEPARATION AND PURIFICATION TECHNOLOGY, 169 (196). [PMID:] [10.1016/j.seppur.2016.05.041] |