Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S287354-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $226.90 | |
S287354-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $345.90 | |
S287354-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $692.90 | |
S287354-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,038.90 | |
S287354-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,563.90 |
Pan RXR agonist
Synonyms | 146670-40-8 | SR 11237 | SR11237 | SR-11237 | BMS 649 | UVI 2108 | 4-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acid | 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid | CHEMBL112715 | BMS649 | Be |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | SR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process. This produces malformations in Xenopus embryos, involving the anterior-posterior axis.1 SR11237 is a selective pan retinoid X receptor (R |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Retinoid X receptor-α |
Product Description | SR11237 may be used in RXR-mediated cell signaling studies. |
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IUPAC Name | 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid |
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INCHI | InChI=1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26) |
InChi Key | ZZUKALQMHNSWTK-UHFFFAOYSA-N |
Canonical SMILES | CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C |
Isomeric SMILES | CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C |
WGK Germany | 3 |
PubChem CID | 127019 |
Molecular Weight | 380.48 |
PubChem CID | 127019 |
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ChEMBL Ligand | CHEMBL112715 |
BindingDB Ligand | 50033077 |
CAS Registry No. | 146670-40-8 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2222021 | Certificate of Analysis | Jun 17, 2022 | S287354 |
H2222022 | Certificate of Analysis | Jun 17, 2022 | S287354 |
H2222141 | Certificate of Analysis | Jun 17, 2022 | S287354 |
H2222142 | Certificate of Analysis | Jun 17, 2022 | S287354 |
H2222143 | Certificate of Analysis | Jun 17, 2022 | S287354 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 38.05, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.8, Max Conc. mM: 10 |
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WGK Germany | 3 |
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RIDADR | NONHforallmodesoftransport |
1. Zhou L, Shen LH, Hu LH, Ge H, Pu J, Chai DJ, Shao Q, Wang L, Zeng JZ, He B. (2010) Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.. Mol Cell Biochem, 335 (1-2): (283-9). [PMID:19784811] |