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SR 11237 - ≥98%(HPLC), high purity , CAS No.146670-40-8, Agonist of Retinoid X receptor-α

  • Moligand™
  • ≥98%(HPLC)
Item Number
S287354
Grouped product items
SKUSizeAvailabilityPrice Qty
S287354-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$226.90
S287354-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$345.90
S287354-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$692.90
S287354-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,038.90
S287354-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,563.90

Pan RXR agonist

View related series
Retinoid X receptor-α Agonist

Basic Description

Synonyms146670-40-8|SR 11237|SR11237|SR-11237|BMS 649|UVI 2108|4-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acid|4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid|CHEMBL112715|BMS649|Be
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsSR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process. This produces malformations in Xenopus embryos, involving the anterior-posterior axis.1 SR11237 is a selective pan retinoid X receptor (R
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Retinoid X receptor-α
Product Description

SR11237 may be used in RXR-mediated cell signaling studies.

Associated Targets

CYP26A1 Tchem Cytochrome P450 26A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP26B1 Tchem Cytochrome P450 26B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARG Tclin Retinoic acid receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRB Tclin Retinoic acid receptor RXR-beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARB Tclin Retinoic acid receptor beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARA Tclin Retinoic acid receptor alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid
INCHI InChI=1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
InChi Key ZZUKALQMHNSWTK-UHFFFAOYSA-N
Canonical SMILES CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C
Isomeric SMILES CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C
WGK Germany 3
PubChem CID 127019
Molecular Weight 380.48

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
H2222021Certificate of AnalysisJun 17, 2022 S287354
H2222022Certificate of AnalysisJun 17, 2022 S287354
H2222141Certificate of AnalysisJun 17, 2022 S287354
H2222142Certificate of AnalysisJun 17, 2022 S287354
H2222143Certificate of AnalysisJun 17, 2022 S287354

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 38.05, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.8, Max Conc. mM: 10

Safety and Hazards(GHS)

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

References

1. Zhou L, Shen LH, Hu LH, Ge H, Pu J, Chai DJ, Shao Q, Wang L, Zeng JZ, He B.  (2010)  Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages..  Mol Cell Biochem,  335  (1-2): (283-9).  [PMID:19784811]

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