SR-12813 - ≥98%, high purity , CAS No.126411-39-0, Agonist of Pregnane X receptor

Item Number

S274978

• Synonyms: 126411-39-0|SR12813|SR 12813|SR-12813|GW 485801|4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol|CHEBI:77317|6Q7MN2PVB9|CHEMBL458767|Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl es
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent, selective PXR agonist. (EC 50 = 200 nM for human PXR). Inhibits cholesterol biosynthesis. Cell permeable. Active in vivo .
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of Pregnane X receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

application：

SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes.