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SR 2211 - ≥98%(HPLC), high purity , CAS No.1359164-11-6, Agonist of RAR-related orphan receptor-γ
Selective RORγ inverse agonist
Basic Description Synonyms SR-03000002211-1 | MLS004256334 | 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-alpha,alpha-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol | 1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]- Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms SR2211 (ML310) is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORγ). RORγ is essential for interleukin 17 expression and differentiation of TH17 cells, important in autoimmune diseases including multiple Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of RAR-related orphan receptor-γ Product Description SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol INCHI InChI=1S/C26H24F7N3O/c27-23-15-21(24(37,25(28,29)30)26(31,32)33)5-6-22(23)20-3-1-18(2-4-20)16-35-11-13-36(14-12-35)17-19-7-9-34-10-8-19/h1-10,15,37H,11-14,16-17H2 InChi Key KVHKWAZUPPBMLL-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1CC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)F)CC4=CC=NC=C4 Isomeric SMILES C1CN(CCN1CC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)F)CC4=CC=NC=C4 PubChem CID 51035449 Molecular Weight 527.48
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 52.75, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 26.37, Max Conc. mM: 50
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
RIDADR NONHforallmodesoftransport
References 1. Kumar N, Lyda B, Chang MR, Lauer JL, Solt LA, Burris TP, Kamenecka TM, Griffin PR. (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator.. ACS Chem Biol, 7 (4): (672-7). [PMID:22292739 ] [10.1021/op500134e ] 2. Billon C, Murray MH, Avdagic A, Burris TP. (2019) RORγ regulates the NLRP3 inflammasome.. J Biol Chem, 294 (1): (10-19). [PMID:30455347 ] [10.1021/op500134e ]
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