SR 27897 (Lintitript) - ≥98%, high purity , CAS No.136381-85-6, Antagonist of CCK 1 receptor

Item Number

S276166

• Synonyms: Lintitript|136381-85-6|SR 27897|SR-27897|Lintitript [INN]|SR27897|2-(2-((4-(2-Chlorophenyl)thiazol-2-yl)carbamoyl)-1H-indol-1-yl)acetic acid|2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]acetic acid|DTXSID9046738|2-((4-(o-Chlorophenyl)-2
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Highly potent, selective, competitive, non-peptide CCK 1 receptor antagonist (K i = 0.2 nM). Increases plasma leptin levels. Shows central effects. Stimulates food intake in vivo. Orally active.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of CCK 1 receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Explanation：

Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin。