SR-318 - 10mM in DMSO, high purity , CAS No.2413286-32-3(DMSO)

Item Number

S655951

Grouped product items
SKU	Size	Availability	Price	Qty
S655951-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$105.90

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Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	SR-318 is a potent and highly selective p38 MAPK inhibitor with IC 50 s of 5 nM, 32 nM and 6.11 μM for p38α , p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC 50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity In Vitro SR-318 presents a potent and selective type-II inhibitor of p38α/β that can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:p38α 5 nM (IC 50 ) p38β 32 nM (IC 50 )

Associated Targets(Human)

MAPK11 Tchem Mitogen-activated protein kinase 11 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Canonical SMILES

C1CCC(CC1)CCCNC(=O)C2=CC=C(C=C2)CNC(=O)C3=C(N(N=C3)C4=CC=CC=C4)N

Molecular Weight

459.58

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Basic Description