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SR 8278 - ≥98%, high purity , CAS No.1254944-66-5, Antagonist of Rev-Erb-α
Basic Description
| Synonyms | ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate | 1254944-66-5 | Q27088866 | SR8278, >=98%, semisolid | AKOS024458171 | GTPL2904 | SCHEMBL20488638 | 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoqui |
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| Specifications & Purity | Moligand™, ≥98% |
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| Biochemical and Physiological Mechanisms | Rev-Erbαantagonist; inhibits Rev-Erbαtranscriptional repression (EC50= 0.47μM). Blocks activity of Rev-ErbαagonistGSK 4112 in HEK293 cells. Increases expression of glucose-regulating genes,G6PaseandPEPCKin HepG2 cells. |
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| Storage Temp | Store at 2-8°C |
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| Shipped In | Wet ice |
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| Grade | Moligand™ |
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| Action Type | ANTAGONIST |
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| Mechanism of action | Antagonist of Rev-Erb-α |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate |
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| INCHI | InChI=1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3 |
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| InChi Key | UIEBLUZPSFAFOC-UHFFFAOYSA-N |
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| Canonical SMILES | CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC |
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| Isomeric SMILES | CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC |
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| WGK Germany | 3 |
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| PubChem CID | 53393127 |
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| Molecular Weight | 361.48 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 36.15, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 18.07, Max Conc. mM: 50 |
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G2201437