Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S275697-5mg | 5mg | In stock | $104.90 | |
S275697-10mg | 10mg | In stock | $160.90 | |
S275697-25mg | 25mg | In stock | $361.90 | |
S275697-50mg | 50mg | In stock | $661.90 | |
S275697-100mg | 100mg | In stock | $1,190.90 | |
S275697-200mg | 200mg | In stock | $2,142.90 |
Potent REV-ERBα/β agonist
Synonyms | Q15410184 | DTXSID901045515 | NSC810521 | NSC-810521 | SB19006 | NCGC00384202-01 | DB14013 | REV-ERB Agonist II | 1-Pyrrolidinecarboxylic acid, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-, ethyl ester | 1-pyrrolidinecarboxylic ac |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent REV-ERBα/β agonist (IC 50 values are 670 and 800 nM for Rev-ErbAα and Rev-ErbAβ-dependent repressor activity respectively). Modulates circadian behavior, shows antiobesogenic and anti-inflammatory effects in vivo.Cell permeable: yes Primary Target |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Rev-Erb-α;Agonist of Rev-Erb-β |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate |
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INCHI | InChI=1S/C20H24ClN3O4S/c1-2-28-20(25)23-10-9-16(13-23)12-22(11-15-3-5-17(21)6-4-15)14-18-7-8-19(29-18)24(26)27/h3-8,16H,2,9-14H2,1H3 |
InChi Key | MMJJNHOIVCGAAP-UHFFFAOYSA-N |
Canonical SMILES | CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-] |
Isomeric SMILES | CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-] |
PubChem CID | 57394020 |
Molecular Weight | 437.94 |
PubChem CID | 57394020 |
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BindingDB Ligand | 50366238 |
CAS Registry No. | 1379686-30-2 |
ChEMBL Ligand | CHEMBL1961796 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G23041153 | Certificate of Analysis | Jun 12, 2024 | S275697 |
G23041154 | Certificate of Analysis | Jun 12, 2024 | S275697 |
G23041162 | Certificate of Analysis | May 10, 2024 | S275697 |
G23041161 | Certificate of Analysis | Apr 11, 2024 | S275697 |
G23041160 | Certificate of Analysis | Apr 11, 2024 | S275697 |
G23041159 | Certificate of Analysis | Apr 11, 2024 | S275697 |
G23041155 | Certificate of Analysis | Apr 07, 2024 | S275697 |
G23041156 | Certificate of Analysis | Apr 07, 2024 | S275697 |
G23041157 | Certificate of Analysis | Apr 07, 2024 | S275697 |
G23041158 | Certificate of Analysis | Apr 07, 2024 | S275697 |
A2219537 | Certificate of Analysis | Aug 10, 2023 | S275697 |
A2219538 | Certificate of Analysis | Aug 10, 2023 | S275697 |
A2219582 | Certificate of Analysis | Aug 10, 2023 | S275697 |
A2219584 | Certificate of Analysis | Aug 10, 2023 | S275697 |
A2219583 | Certificate of Analysis | Nov 15, 2022 | S275697 |
Solubility | Soluble in DMSO to 100 mM |
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Sensitivity | light sensitive |
Melt Point(°C) | 79-81°C |
Starting at $108.90
1. Banerjee S, Wang Y, Solt LA, Griffett K, Kazantzis M, Amador A, El-Gendy BM, Huitron-Resendiz S, Roberts AJ, Shin Y et al.. (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.. Nat Commun, 5 (13): (5759). [PMID:25536025] [10.1021/op500134e] |