Potent REV-ERBα/β agonist (IC 50 values are 670 and 800 nM for Rev-ErbAα and Rev-ErbAβ-dependent repressor activity respectively). Modulates circadian behavior, shows antiobesogenic and anti-inflammatory effects in vivo.Cell permeable: yes
Primary Target
Storage Temp
Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Rev-Erb-α;Agonist of Rev-Erb-β
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Banerjee S, Wang Y, Solt LA, Griffett K, Kazantzis M, Amador A, El-Gendy BM, Huitron-Resendiz S, Roberts AJ, Shin Y et al.. (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.. Nat Commun, 5 (3):(5759). [PMID:25536025]
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G23041153