Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S288664-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $114.90 | |
S288664-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $229.90 | |
S288664-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $398.90 | |
S288664-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $558.90 |
Potent and selective LXR inverse agonist
Synonyms | Ethyl 5-((2,4,6-trimethyl-N-((3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent and selective LXR inverse agonist (IC50values are 43 and 214 nM for LXRβand LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hep |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of Liver X receptor-α;Antagonist of Liver X receptor-β |
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IUPAC Name | ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate |
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INCHI | InChI=1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6,19-20H2,1-5H3 |
InChi Key | HDZWHJYZJWLTAG-UHFFFAOYSA-N |
Canonical SMILES | CCOC(=O)C1=CC=C(O1)CN(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)S(=O)(=O)C4=C(C=C(C=C4C)C)C |
Isomeric SMILES | CCOC(=O)C1=CC=C(O1)CN(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)S(=O)(=O)C4=C(C=C(C=C4C)C)C |
PubChem CID | 71478195 |
MeSH Entry Terms | SR9238 |
Molecular Weight | 595.73 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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B2426818 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426828 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426829 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426830 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426831 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426832 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426840 | Certificate of Analysis | Jan 19, 2024 | S288664 |
B2426841 | Certificate of Analysis | Jan 19, 2024 | S288664 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 59.57, Max Conc. mM: 100 |
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Signal | Warning |
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Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
RIDADR | NONHforallmodesoftransport |
Starting at $98.90