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SR 9238 - ≥98%(HPLC), high purity , CAS No.1416153-62-2, Antagonist of Liver X receptor-α;Antagonist of Liver X receptor-β
Potent and selective LXR inverse agonist
Basic Description Synonyms Ethyl 5-((2,4,6-trimethyl-N-((3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective LXR inverse agonist (IC50values are 43 and 214 nM for LXRβand LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hep Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of Liver X receptor-α;Antagonist of Liver X receptor-β
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate INCHI InChI=1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6,19-20H2,1-5H3 InChi Key HDZWHJYZJWLTAG-UHFFFAOYSA-N Canonical SMILES CCOC(=O)C1=CC=C(O1)CN(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)S(=O)(=O)C4=C(C=C(C=C4C)C)C Isomeric SMILES CCOC(=O)C1=CC=C(O1)CN(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)S(=O)(=O)C4=C(C=C(C=C4C)C)C PubChem CID 71478195 MeSH Entry Terms SR9238 Molecular Weight 595.73
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 59.57, Max Conc. mM: 100
Safety and Hazards(GHS) Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
RIDADR NONHforallmodesoftransport
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B2426818