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SR1555 , CAS No.S613695, Agonist of RAR-related orphan receptor-γ

PubChem CID: 71470549

Item Number

S613695

Grouped product items
SKU	Size	Availability	Price	Qty
S613695-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S613695-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

RAR-related orphan receptor-γ Agonist

Synonyms

SR-1555

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of RAR-related orphan receptor-γ

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (1 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H3 Tchem LXR-alpha (2891 Activities)

Discover Target: NR1H3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[4-[[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]methyl]piperazin-1-yl]ethanone
INCHI	InChI=1S/C22H22F6N2O2/c1-15(31)30-12-10-29(11-13-30)14-16-2-4-17(5-3-16)18-6-8-19(9-7-18)20(32,21(23,24)25)22(26,27)28/h2-9,32H,10-14H2,1H3
InChi Key	LTFVNEZXOPUABB-UHFFFAOYSA-N
Canonical SMILES	CC(=O)N1CCN(CC1)Cc1ccc(cc1)c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O
Isomeric SMILES	CC(=O)N1CCN(CC1)CC2=CC=C(C=C2)C3=CC=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O
PubChem CID	71470549

PubChem CID

71470549

BindingDB Ligand

50044227

ChEMBL Ligand

CHEMBL3218917

References

1. Solt LA, Kumar N, He Y, Kamenecka TM, Griffin PR, Burris TP. (2012) Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells.. ACS Chem Biol, 7 (9): (1515-9). [PMID:22769242] [10.1021/op500134e]
2. Billon C, Murray MH, Avdagic A, Burris TP. (2019) RORγ regulates the NLRP3 inflammasome.. J Biol Chem, 294 (1): (10-19). [PMID:30455347] [10.1021/op500134e]

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SR1555 , CAS No.S613695, Agonist of RAR-related orphan receptor-γ

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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