Skip to the beginning of the images gallery

Src Inhibitor-1 - ≥98%(HPLC), high purity , CAS No.179248-59-0, Inhibitor of receptor interacting serine/threonine kinase 2

Moligand™
≥98%(HPLC)

CAS#: 179248-59-0
Formula: C₂₂H₁₉N₃O₃
Molecular Weight: 373.4
MDL number: MFCD01815300
PubChem CID: 1474853

Item Number

D135775

Grouped product items
SKU	Size	Availability	Price
D135775-1mg	1mg	In stock	$19.90
D135775-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$82.90
D135775-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$260.90

Potent, selective and dual site Src tyrosine kinase family inhibitor

View related series

receptor interacting serine/threonine kinase 2 Inhibitor

Basic Description

Synonyms	179248-59-0\|Src Kinase Inhibitor I\|Src Inhibitor 1\|Src I1\|6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine\|Src Inhibitor-1\|4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)-\|Src-l1\|6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine\|Src I 1\|CHEMBL97
Specifications & Purity	≥98%(HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of receptor interacting serine/threonine kinase 2
Product Description	Src kinase inhibitor I is a 4-anilinoquinazole competitive inhibitor of Src family tryosine kinases. Src kinase inhibitor I is a dual site inhibitor, described to compete at both the ATP and peptide binding sites of the kinase. Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.

Names and Identifiers

IUPAC Name	6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
INCHI	InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
InChi Key	DMWVGXGXHPOEPT-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)OC
Isomeric SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)OC
WGK Germany	3
PubChem CID	1474853
Molecular Weight	373.4

PubChem CID

1474853

ChEMBL Ligand

CHEMBL97771

CAS Registry No.

179248-59-0

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
H1810208	Certificate of Analysis	Feb 20, 2024	D135775
H1810209	Certificate of Analysis	May 09, 2022	D135775
E1620084	Certificate of Analysis	Jan 25, 2022	D135775

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

References

1. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. (2007) The selectivity of protein kinase inhibitors: a further update.. Biochem J, 408 (3): (297-315). [PMID:17850214]
2. Röselová P et al.. (2018) Adhesion structures in leukemia cells and their regulation by Src family kinases.. Cell Adh Migr, 12 (3): (286-298). [PMID:28678601]
3. McGee D et al.. (2017) Cervical HSV-2 infection causes cervical remodeling and increases risk for ascending infection and preterm birth.. PLoS One, 12 (11): (e0188645). [PMID:29190738]
4. Kumazoe M et al.. (2017) Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.. J Immunol, 199 (9): (3261-3269). [PMID:28954885]
5. Wang X et al.. (2017) Human papillomavirus type 16 E6 oncoprotein promotes proliferation and invasion of non-small cell lung cancer cells through Toll-like receptor 3 signaling pathway.. J Med Virol, [PMID:28480962]
6. Hock EM et al.. (2018) Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.. Cell Rep, 24 (4): (987-1000.e7). [PMID:30044993]
7. Gomes JR et al.. (2016) Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia.. Cell Death Differ, 23 (11): (1749-1764). [PMID:27518433]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Src Inhibitor-1 - ≥98%(HPLC), high purity , CAS No.179248-59-0, Inhibitor of receptor interacting serine/threonine kinase 2

Basic Description

Associated Targets

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 2 Activities

Names and Identifiers

Database links