Src (phospho Y529) Antibody - Primary antibody, specific to Src (phospho Y529), Rabbit IgG
Specifications & Purity
Validated, 1.0 mg/mL
Host species
Rabbit
Specificity
Src (phospho Y529)
Immunogen
A synthetic peptide derived from human Src (phospho Y529) (AA 487-536).
Positive Control
WB: COS7, 3T3 lysates. IHC: Human breast carcinoma tissue
Conjugation
Unconjugated
Grade
Validated
Product Description
Rabbit polyclonal to Src (phospho Y529), Polyclonal, could be used for WB, IHC and so on. Applications: WB: 1/500 - 1/2000 IHC: 1/100 - 1/300 Protein Function Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Product Properties
Isotype
Rabbit IgG
SDS-PAGE
150kDa
Purification Method
Immunogen affinity purified
Form
Liquid
Concentration
1.0 mg/mL
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
ZJ24F0708804