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SRT 1460 - 98%, high purity , CAS No.925432-73-1
a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1.
Basic Description Synonyms BRD-K20979596-019-01-6 | MFCD19053214 | SCHEMBL1302286 | 3,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)-imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | 3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | 3,4,5-TRIME Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description SRT 1460 is a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1. SRT 1460 shows positive selectivity of SIRT1 versus SIRT2 and SIRT3. In animal studies, SRT 1460 was shown to have similar activity to resveratrol, a known SIRT1 activator. SRT 1460, however, is closer in potency to SRT 1720 than it is to resveratrol. SRT 1460 was observed in animal studies improving insulin sensitivity, lowering plasma glucose levels, and increasing metabolic function in mitochondria.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3,4,5-trimethoxy-N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]benzamide INCHI InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32) InChi Key SBEWVVLMFLTQFE-UHFFFAOYSA-N Canonical SMILES COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5 Isomeric SMILES COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5 PubChem CID 24180124 Molecular Weight 507.62
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