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SS-208 - 98%, high purity , CAS No.2245942-72-5

≥98%

CAS#: 2245942-72-5
Formula: C₁₃H₁₁Cl₂N₃O₄
Molecular Weight: 344.15
PubChem CID: 135348858

Item Number

S647126

Grouped product items
SKU	Size	Availability	Price
S647126-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$138.90
S647126-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
S647126-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
S647126-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$900.90
S647126-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,450.90
S647126-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,200.90

View related series

Cell Cycle/DNA Damage Epigenetics HDAC

Basic Description

Synonyms	2245942-72-5 \| EX-A5081 \| MS-25266 \| GTPL10490 \| compound 7b [PMID: 31414801] \| 3-Isoxazolecarboxamide, 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy- \| 5-(2-(3,4-Dichlorobenzamido)ethyl)-N-hydroxyisoxazole-3-carboxamide \| SCHEMBL20524113 \| 5-[2-[(3,4
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	SS-208 is a selective HDAC6 inhibitor, with an IC 50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	SS-208 is a selective HDAC6 inhibitor, with an IC 50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma In Vivo SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously . Dosage: 25 mg/kg. Administration: IP on day 4, 7, 12, 15 and 18. Result: Significantly reduced the tumor growth. Form:Solid IC50& Target:HDAC6 12 nM (IC 50 ) HDAC8 1.23 μM (IC 50 ) HDAC1 1.39 μM (IC 50 ) HDAC11 5.12 μM (IC 50 ) HDAC5 6.91 μM (IC 50 ) HDAC7 8.34 μM (IC 50 )

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (4 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HDAC8 Tclin Histone deacetylase 8 (4516 Activities)

Discover Target: HDAC8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HDAC4 Tclin Histone deacetylase 4 (2328 Activities)

Discover Target: HDAC4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HDAC9 Tclin Histone deacetylase 9 (708 Activities)

Discover Target: HDAC9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HDAC11 Tclin Histone deacetylase 11 (967 Activities)

Discover Target: HDAC11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HDAC7 Tclin Histone deacetylase 7 (1047 Activities)

Discover Target: HDAC7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

5637 (630 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

T-24 (2342 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac1 Histone deacetylase 1 (93 Activities)

Discover Target: Hdac1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac5 Histone deacetylase 5 (5 Activities)

Discover Target: Hdac5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HD1 Histone deacetylase (38 Activities)

Discover Target: HD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-1,2-oxazole-3-carboxamide
INCHI	InChI=1S/C13H11Cl2N3O4/c14-9-2-1-7(5-10(9)15)12(19)16-4-3-8-6-11(18-22-8)13(20)17-21/h1-2,5-6,21H,3-4H2,(H,16,19)(H,17,20)
InChi Key	JFGOILLZIAIYGA-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1C(=O)NCCC2=CC(=NO2)C(=O)NO)Cl)Cl
Isomeric SMILES	C1=CC(=C(C=C1C(=O)NCCC2=CC(=NO2)C(=O)NO)Cl)Cl
Alternate CAS	2245942-72-5
PubChem CID	135348858
Molecular Weight	344.15

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SS-208 - 98%, high purity , CAS No.2245942-72-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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