StAR Antibody - Primary antibody, specific to STAR, Rabbit IgG
Synonyms
StAR | StARD1 | START domain-containing protein 1 | Cholesterol trafficker antibody | Luteinizing hormone induced protein antibody | mitochondrial antibody | Mitochondrial steroid acute regulatory protein antibody | StAR antibody | StAR related lipid tran
Specifications & Purity
Carrier Free, ExactAb™, Azide Free, Validated, High Performance, See COA
Host species
Rabbit
Specificity
STAR
Immunogen
Recombinant STAR expressed in E.coli (AA 1-285)
Positive Control
WB: Recombinant Human STAR, Porcine adrenal gland, Rat adrenal gland lysates. IHC: Human kidney tissue.
Conjugation
Unconjugated
Grade
Azide Free, Carrier Free, ExactAb™, High Performance, Validated
Product Description
Rabbit anti Human StAR Antibody, Polyclonal, could be used for WB, IHC and so on. Application: WB: 0.01-2µg/mL IHC: 5-20µg/mL Protein Function Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Product Properties
Isotype
Rabbit IgG
SDS-PAGE
150 kDa
Purification Method
Antigen affinity purified + Protein A purified
Form
Liquid
Concentration
See COA
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
StAR Antibody (Ab129336) - Western Blot All lanes: StAR Antibody (Ab129336) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 32 kDa Observed band size: 28 kDa Exposure time: 20.0 s
StAR Antibody (Ab129336) - IHC DAB staining on IHC Samples: Human Kidney Tissue Primary Ab: 20 μg/mL StAR Antibody (Ab129336) Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody.
1.J F Strauss,C B Kallen,L K Christenson,H Watari,L Devoto,F Arakane,M Kiriakidou,T Sugawara. (1999-11-05) The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking.. Recent progress in hormone research, 54 (369-394). [PMID:10548884]
2.Sugawara, T T and 6 more authors.. (1995) Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity.. Biochemistry, (3):[PMID:7547998]
3.Gradi, A A and 5 more authors.. (1995) The human steroidogenic acute regulatory (StAR) gene is expressed in the urogenital system and encodes a mitochondrial polypeptide.. Biochimica et biophysica acta, (5):[PMID:7548191]
4.Sugawara, T T and 9 more authors.. (1995) Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13.. Proceedings of the National Academy of Sciences of the United States of America, (23):[PMID:7761400]
5.Lin, D D and 7 more authors.. (1995) Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.. Science (New York, N.Y.), (24):[PMID:7892608]
6.. (1996) The pathophysiology and genetics of congenital lipoid adrenal hyperplasia.. The New England journal of medicine, (19):[PMID:8948562]
7.Nakae, J J and 17 more authors.. (1997) Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia.. Human molecular genetics, [PMID:9097960]
8.Katsumata, N N and 7 more authors.. (1998) Novel frameshift mutation 840delA and a novel polymorphism D203A in the steroidogenic acute regulatory protein gene in a Japanese patient with congenital lipoid adrenal hyperplasia.. Human mutation, [PMID:9452116]
9.Katsumata, N N and 6 more authors.. (1999) A novel compound heterozygous mutation in the steroidogenic acute regulatory protein gene in a patient with congenital lipoid adrenal hyperplasia.. The Journal of clinical endocrinology and metabolism, [PMID:10566637]
10.Thorsell, Ann-Gerd AG and 8 more authors.. (2011) Comparative structural analysis of lipid binding START domains.. PloS one, [PMID:21738568]
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