Click Here for 5% Off Your First Aladdin Purchase!

Stattic - ≥98%, high purity , CAS No.19983-44-9

Specifications & Purity:  ≥98%
Item Number
S129623
Grouped product items
SKUSizeAvailabilityPrice Qty
S129623-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$94.90
S129623-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$236.90
S129623-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$533.90
S129623-1g
1g
In stock
$1,919.90

Discover Stattic by Aladdin Scientific in ≥98% for only $94.90. Available - in Ligands at Aladdin Scientific. Selective STAT3 inhibitor Tags: .

Basic Description

SynonymsStattic|19983-44-9|6-Nitrobenzo[b]thiophene 1,1-dioxide|6-nitro-1-benzothiophene 1,1-dioxide|1,1-DIOXIDE-6-NITRO-BENZO[B]THIOPHENE|STAT3 Inhibitor V, Stattic|6-Nitrobenzo[b]thiophene-1,1-dioxide|Benzo[b]thiophene, 6-nitro-, 1,1-dioxide|CHEMBL1337170|MFCD0
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice

Associated Targets

HIF1A Tchem Hypoxia-inducible factor 1-alpha 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-nitro-1-benzothiophene 1,1-dioxide
INCHI InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChi Key ZRRGOUHITGRLBA-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
Isomeric SMILES C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
WGK Germany 3
PubChem CID 2779853
Molecular Weight 211.19

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
F2220028Certificate of AnalysisApr 02, 2024 S129623
A2206700Certificate of AnalysisOct 10, 2023 S129623
H2223521Certificate of AnalysisJun 30, 2022 S129623
H2223523Certificate of AnalysisJun 30, 2022 S129623
K2328088Certificate of AnalysisJun 30, 2022 S129623

Chemical and Physical Properties

SolubilityDMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Refractive Index1.67
Boil Point(°C)461.1° C
Melt Point(°C)186 - 188 °C

Safety and Hazards(GHS)

Related Documents

Product Questions

Product Questions

Sign In Hover me Please sign in to submit a question
No questions yet. Be the first to ask the question!

Reviews

Customer Reviews

References

1. Zhang R et al..  (2018)  A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid Arthritis..  Sci Rep,  (2623).  [PMID:29422529]
2. Itcho K et al..  (2019)  Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition..  J Steroid Biochem Mol Biol,  185  (137-141).  [PMID:30125658]
3. Katsurahara K et al..  (2021)  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer..  Cancer Sci,  112  (3): (1026-1037).  [PMID:33404124]
4. Miyamoto T et al..  (2022)  B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression..  Cancer Immunol Res,  10  (56-69).  [PMID:34799346]
5. Arimoto-Kobayashi S et al..  (2021)  Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice..  Food Chem Toxicol,  154  (112319).  [PMID:34087405]
6. Liu Q et al..  (2022)  CCL5 Suppresses Klotho Expression via p-STAT3/DNA Methyltransferase1-Mediated Promoter Hypermethylation..  Front Physiol,  13  (856088).  [PMID:35299661]
7. Guo X et al..  (2016)  Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer..  Sci Rep,  (22996).  [PMID:26972355]
8. Yang Y et al..  (2021)  Integrin a5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib-resistant non-small cell lung cancer cells..  Oncol Lett,  22  (556).  [PMID:34084223]
9. Gunjigake K et al..  (2021)  Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination..  Gastric Cancer,  24  (31-44).  [PMID:32488650]
10. Lin CY et al..  (2015)  Impact of high glucose on metastasis of colon cancer cells..  World J Gastroenterol,  21  (7): (2047-57).  [PMID:25717237]
11. Wang Y et al..  (2017)  Long non-coding RNA AK093407 promotes proliferation and inhibits apoptosis of human osteosarcoma cells via STAT3 activation..  Am J Cancer Res,  (4): (892-902).  [PMID:28469961]
12. Tang WG et al..  (2017)  Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis..  Oncotarget,  (60): (102006-102019).  [PMID:29254221]
13. Mantsounga CS et al..  (2022)  Macrophage IL-1ß promotes arteriogenesis by autocrine STAT3- and NF-?B-mediated transcription of pro-angiogenic VEGF-A..  Cell Rep,  38  (5): (110309).  [PMID:35108537]
14. Zhang Z et al..  (2021)  Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction..  J Mol Endocrinol,  66  (4): (259-272).  [PMID:33729996]
15. Son YO et al..  (2017)  Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells..  J Biol Chem,  292  (20): (8315-8330).  [PMID:28330870]
16. Kuo FY et al..  (2020)  Promotion of Adropin Expression by Hyperglycemia Is Associated with STAT3 Activation in Diabetic Rats..  Diabetes Metab Syndr Obes,  13  (2269-2277).  [PMID:32636661]
17. Jiang H et al..  (2017)  Proprotein convertase subtilisin/kexin type 6 promotes in\xa0vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-?B, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathways..  Mol Med Rep,  16  (6): (8477-8484).  [PMID:28944919]
18. Kwofie K et al..  (2015)  Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M..  Respir Res,  16  (14).  [PMID:25849622]
19. Jafari S et al..  (2020)  STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells..  Daru,  28  (159-169).  [PMID:31942696]
20. Timmons GA et al..  (2021)  The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1ß..  Front Immunol,  12  (700431).  [PMID:34858390]
21. Liu Z et al..  (2021)  Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway..  Front Cell Dev Biol,  (806850).  [PMID:35096833]
22. Sato H et al..  (2018)  Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma..  Oncogenesis,  (11).  [PMID:29362358]
23. Feng Y et al..  (2018)  Wnt/ß-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis..  J Am Soc Nephrol,  29  (182-193).  [PMID:29021383]

Calculator