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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S129623-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $94.90 | |
S129623-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $236.90 | |
S129623-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $533.90 | |
S129623-1g | 1g | In stock | $1,919.90 |
Discover Stattic by Aladdin Scientific in ≥98% for only $94.90. Available - in Ligands at Aladdin Scientific. Selective STAT3 inhibitor Tags: .
Synonyms | Stattic|19983-44-9|6-Nitrobenzo[b]thiophene 1,1-dioxide|6-nitro-1-benzothiophene 1,1-dioxide|1,1-DIOXIDE-6-NITRO-BENZO[B]THIOPHENE|STAT3 Inhibitor V, Stattic|6-Nitrobenzo[b]thiophene-1,1-dioxide|Benzo[b]thiophene, 6-nitro-, 1,1-dioxide|CHEMBL1337170|MFCD0 |
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Specifications & Purity | ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Dry ice |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 6-nitro-1-benzothiophene 1,1-dioxide |
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INCHI | InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
InChi Key | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |
Isomeric SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |
WGK Germany | 3 |
PubChem CID | 2779853 |
Molecular Weight | 211.19 |
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Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Apr 02, 2024 | S129623 | |
Certificate of Analysis | Oct 10, 2023 | S129623 | |
Certificate of Analysis | Jun 30, 2022 | S129623 | |
Certificate of Analysis | Jun 30, 2022 | S129623 | |
Certificate of Analysis | Jun 30, 2022 | S129623 |
Solubility | DMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Refractive Index | 1.67 |
Boil Point(°C) | 461.1° C |
Melt Point(°C) | 186 - 188 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315,H319,H335,H302 |
Precautionary Statements | P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319 |
WGK Germany | 3 |
1. Zhang R et al.. (2018) A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid Arthritis.. Sci Rep, 8 (2623). [PMID:29422529] |
2. Itcho K et al.. (2019) Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition.. J Steroid Biochem Mol Biol, 185 (137-141). [PMID:30125658] |
3. Katsurahara K et al.. (2021) ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.. Cancer Sci, 112 (3): (1026-1037). [PMID:33404124] |
4. Miyamoto T et al.. (2022) B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression.. Cancer Immunol Res, 10 (56-69). [PMID:34799346] |
5. Arimoto-Kobayashi S et al.. (2021) Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.. Food Chem Toxicol, 154 (112319). [PMID:34087405] |
6. Liu Q et al.. (2022) CCL5 Suppresses Klotho Expression via p-STAT3/DNA Methyltransferase1-Mediated Promoter Hypermethylation.. Front Physiol, 13 (856088). [PMID:35299661] |
7. Guo X et al.. (2016) Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer.. Sci Rep, 6 (22996). [PMID:26972355] |
8. Yang Y et al.. (2021) Integrin a5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib-resistant non-small cell lung cancer cells.. Oncol Lett, 22 (556). [PMID:34084223] |
9. Gunjigake K et al.. (2021) Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination.. Gastric Cancer, 24 (31-44). [PMID:32488650] |
10. Lin CY et al.. (2015) Impact of high glucose on metastasis of colon cancer cells.. World J Gastroenterol, 21 (7): (2047-57). [PMID:25717237] |
11. Wang Y et al.. (2017) Long non-coding RNA AK093407 promotes proliferation and inhibits apoptosis of human osteosarcoma cells via STAT3 activation.. Am J Cancer Res, 7 (4): (892-902). [PMID:28469961] |
12. Tang WG et al.. (2017) Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis.. Oncotarget, 8 (60): (102006-102019). [PMID:29254221] |
13. Mantsounga CS et al.. (2022) Macrophage IL-1ß promotes arteriogenesis by autocrine STAT3- and NF-?B-mediated transcription of pro-angiogenic VEGF-A.. Cell Rep, 38 (5): (110309). [PMID:35108537] |
14. Zhang Z et al.. (2021) Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction.. J Mol Endocrinol, 66 (4): (259-272). [PMID:33729996] |
15. Son YO et al.. (2017) Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells.. J Biol Chem, 292 (20): (8315-8330). [PMID:28330870] |
16. Kuo FY et al.. (2020) Promotion of Adropin Expression by Hyperglycemia Is Associated with STAT3 Activation in Diabetic Rats.. Diabetes Metab Syndr Obes, 13 (2269-2277). [PMID:32636661] |
17. Jiang H et al.. (2017) Proprotein convertase subtilisin/kexin type 6 promotes in\xa0vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-?B, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathways.. Mol Med Rep, 16 (6): (8477-8484). [PMID:28944919] |
18. Kwofie K et al.. (2015) Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.. Respir Res, 16 (14). [PMID:25849622] |
19. Jafari S et al.. (2020) STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells.. Daru, 28 (159-169). [PMID:31942696] |
20. Timmons GA et al.. (2021) The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1ß.. Front Immunol, 12 (700431). [PMID:34858390] |
21. Liu Z et al.. (2021) Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway.. Front Cell Dev Biol, 9 (806850). [PMID:35096833] |
22. Sato H et al.. (2018) Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.. Oncogenesis, 7 (11). [PMID:29362358] |
23. Feng Y et al.. (2018) Wnt/ß-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis.. J Am Soc Nephrol, 29 (182-193). [PMID:29021383] |