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STF 118804 - 10mM in DMSO, high purity , CAS No.894187-61-2
NAMPT inhibitor; depletes leukemia stem cells
Basic Description
| Synonyms | 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide |
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| Specifications & Purity | 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50< 10 nM); induces apoptosis in MF- |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | 4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide |
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| INCHI | InChI=1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29) |
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| InChi Key | DLFCEZOMHBPDGI-UHFFFAOYSA-N |
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| Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)CC2=C(OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4)C |
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| Isomeric SMILES | CC1=CC=C(C=C1)S(=O)(=O)CC2=C(OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4)C |
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| PubChem CID | 20916937 |
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| Molecular Weight | 461.53 |
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Safety and Hazards(GHS)
| RIDADR | NONHforallmodesoftransport |
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