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STF-62247 - ≥98%, high purity , CAS No.315702-99-9
Basic Description Synonyms 4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine | MFCD01121974 | KATNUHQNJGNLPW-UHFFFAOYSA-N | N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine | Oprea1_578909 | HMS3654K09 | DTXSID90351598 | J-018470 | SR-01000477178 | SR-01000477178-1 | SCHEMBL996232 | 4-(p Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly red Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine INCHI InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18) InChi Key KATNUHQNJGNLPW-UHFFFAOYSA-N Canonical SMILES CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3 Isomeric SMILES CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3 WGK Germany 2 PubChem CID 704473 Molecular Weight 267.35
Chemical and Physical Properties Solubility DMSO 53 mg/mL Water <1 mg/mL Ethanol 3 mg/mL Refractive Index 1.67 Boil Point(°C) 444.82° C Melt Point(°C) 174.66°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 2
Citations of This Product 1. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang. (2023) Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy. Small, (2207898). [PMID:36932938 ] [10.1002/smll.202207898 ]
References 1. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang. (2023) Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy. Small, (2207898). [PMID:36932938 ] [10.1002/smll.202207898 ]
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E1718063