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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
S420015-1mg | 1mg | In stock | $120.90 | |
S420015-5mg | 5mg | In stock | $256.90 | |
S420015-10mg | 10mg | In stock | $414.90 | |
S420015-25mg | 25mg | In stock | $791.90 | |
S420015-50mg | 50mg | In stock | $1,167.90 | |
S420015-100mg | 100mg | In stock | $1,484.90 |
Specifications & Purity | Moligand™, ≥98% |
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Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of methyltransferase 3; N6-adenosine-methyltransferase complex catalytic subunit |
Product Description | STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML)。 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 488203090 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488203090 |
IUPAC Name | N-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxopyrido[1,2-a]pyrimidine-2-carboxamide |
INCHI | InChI=1S/C25H28N6O2/c32-24-12-21(29-23-8-4-5-11-31(23)24)25(33)27-15-20-17-30-16-19(9-10-22(30)28-20)14-26-13-18-6-2-1-3-7-18/h4-5,8-12,16-18,26H,1-3,6-7,13-15H2,(H,27,33) |
InChi Key | OBERVORNENYOLE-UHFFFAOYSA-N |
Canonical SMILES | C1CCC(CC1)CNCC2=CN3C=C(N=C3C=C2)CNC(=O)C4=CC(=O)N5C=CC=CC5=N4 |
PubChem CID | 155167581 |
Molecular Weight | 444.5 |
Find and download the COA for your product by matching the lot number on the packaging.
13 results found
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B2419128 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062158 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062161 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062162 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062163 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062164 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062165 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062166 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062167 | Certificate of Analysis | Feb 11, 2023 | S420015 |
D23062168 | Certificate of Analysis | Feb 11, 2023 | S420015 |
Solubility | DMSO:125 mg/mL (281.20 mM),Need ultrasonic |
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1. Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG et al.. (2021) Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia.. Nature, 71 (13): (1755-70). [PMID:33902106] [10.1038/s41586-021-03536-w] |