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STM2457 - 98%, high purity , CAS No.2499663-01-1, Inhibitor of methyltransferase 3; N6-adenosine-methyltransferase complex catalytic subunit

Item Number
S420015
Grouped product items
SKUSizeAvailabilityPrice Qty
S420015-1mg
1mg
In stock
$120.90
S420015-5mg
5mg
In stock
$256.90
S420015-10mg
10mg
In stock
$414.90
S420015-25mg
25mg
In stock
$791.90
S420015-50mg
50mg
In stock
$1,167.90
S420015-100mg
100mg
In stock
$1,484.90

Basic Description

Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of methyltransferase 3; N6-adenosine-methyltransferase complex catalytic subunit
Product Description

STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML)。

Associated Targets(Human)

METTL3 Tbio N6-adenosine-methyltransferase catalytic subunit (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488203090
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488203090
IUPAC Name N-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxopyrido[1,2-a]pyrimidine-2-carboxamide
INCHI InChI=1S/C25H28N6O2/c32-24-12-21(29-23-8-4-5-11-31(23)24)25(33)27-15-20-17-30-16-19(9-10-22(30)28-20)14-26-13-18-6-2-1-3-7-18/h4-5,8-12,16-18,26H,1-3,6-7,13-15H2,(H,27,33)
InChi Key OBERVORNENYOLE-UHFFFAOYSA-N
Canonical SMILES C1CCC(CC1)CNCC2=CN3C=C(N=C3C=C2)CNC(=O)C4=CC(=O)N5C=CC=CC5=N4
PubChem CID 155167581
Molecular Weight 444.5

Certificates

C of A & Other Certificates(BSE/TSE, COO)

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
B2419128Certificate of AnalysisFeb 11, 2023 S420015
D23062158Certificate of AnalysisFeb 11, 2023 S420015
D23062161Certificate of AnalysisFeb 11, 2023 S420015
D23062162Certificate of AnalysisFeb 11, 2023 S420015
D23062163Certificate of AnalysisFeb 11, 2023 S420015
D23062164Certificate of AnalysisFeb 11, 2023 S420015
D23062165Certificate of AnalysisFeb 11, 2023 S420015
D23062166Certificate of AnalysisFeb 11, 2023 S420015
D23062167Certificate of AnalysisFeb 11, 2023 S420015
D23062168Certificate of AnalysisFeb 11, 2023 S420015
D23062169Certificate of AnalysisFeb 11, 2023 S420015
D23062170Certificate of AnalysisFeb 11, 2023 S420015
D23062171Certificate of AnalysisFeb 11, 2023 S420015

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Chemical and Physical Properties

SolubilityDMSO:125 mg/mL (281.20 mM),Need ultrasonic

Related Documents

References

1. Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG et al..  (2021)  Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia..  Nature,  71  (13): (1755-70).  [PMID:33902106] [10.1038/s41586-021-03536-w]

Solution Calculators