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SKU | Size | Availability | Price | Qty |
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S105491-25g | 25g | In stock | $22.90 | |
S105491-100g | 100g | In stock | $82.90 | |
S105491-500g | 500g | In stock | $198.90 |
Synonyms | STREP SOL | STREPTOMYCIN SULFATE [GREEN BOOK] | D-STREPTAMINE, O-2-DEOXY-2-(METHYLAMINO)-alpha-L-GLUCOPYRANOSYL-(1->2)-O-5-DEOXY-3-C-FORMYL-alpha-L-LYXOFURANOSYL-(1->4)-N,N'-BIS(AMINOIMINOMETHYL)-, SULPHATE (2:3) (SALT) | Streptomycin A sulfate | CCRIS 5 |
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Specifications & Purity | 720 I.U./mg |
Biochemical and Physiological Mechanisms | Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Product Description | Streptomycin sulfate is an aminocyclitol glycoside antibiotic which interferes with protein synthesis in prokaryotes. This antibiotic is effective against both gram-positive and gram-negative bacteria and is frequently used in cell culture media. Streptomycin inhibits protein synthesis by binding to the 30S ribosomal subunit at the S12 protein thereby inducing a misreading of the genetic code, inhibiting the initiation of translation of DNA which then results in death for a susceptible bacterium. |
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Pubchem Sid | 488182553 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488182553 |
IUPAC Name | 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acid |
INCHI | InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;;;/m00.../s1 |
InChi Key | QTENRWWVYAAPBI-YCRXJPFRSA-N |
Canonical SMILES | CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O |
Isomeric SMILES | C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O |
WGK Germany | 3 |
RTECS | WK4990000 |
Alternate CAS | 57-92-1 |
PubChem CID | 19648 |
Molecular Weight | 1457.38 |
Beilstein | 3894995 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
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H2423130 | Certificate of Analysis | Aug 12, 2024 | S105491 |
H2423129 | Certificate of Analysis | Aug 12, 2024 | S105491 |
F2418059 | Certificate of Analysis | Jun 11, 2024 | S105491 |
F2418058 | Certificate of Analysis | Jun 11, 2024 | S105491 |
C2419516 | Certificate of Analysis | Mar 01, 2024 | S105491 |
C2419376 | Certificate of Analysis | Mar 01, 2024 | S105491 |
J2309623 | Certificate of Analysis | Sep 18, 2023 | S105491 |
J2309607 | Certificate of Analysis | Sep 18, 2023 | S105491 |
G23131232 | Certificate of Analysis | Jul 08, 2023 | S105491 |
G23131235 | Certificate of Analysis | Jul 08, 2023 | S105491 |
G23131236 | Certificate of Analysis | Jul 08, 2023 | S105491 |
G23131273 | Certificate of Analysis | Jul 08, 2023 | S105491 |
C23031285 | Certificate of Analysis | Feb 13, 2023 | S105491 |
C23031284 | Certificate of Analysis | Feb 13, 2023 | S105491 |
C23031267 | Certificate of Analysis | Feb 13, 2023 | S105491 |
A2303229 | Certificate of Analysis | Nov 23, 2022 | S105491 |
A2303238 | Certificate of Analysis | Nov 23, 2022 | S105491 |
A2303543 | Certificate of Analysis | Nov 23, 2022 | S105491 |
A2303545 | Certificate of Analysis | Nov 23, 2022 | S105491 |
H2209632 | Certificate of Analysis | Jul 22, 2022 | S105491 |
H2209633 | Certificate of Analysis | Jul 22, 2022 | S105491 |
H2209631 | Certificate of Analysis | Jul 22, 2022 | S105491 |
F2118118 | Certificate of Analysis | Jun 21, 2021 | S105491 |
F2116369 | Certificate of Analysis | Jun 21, 2021 | S105491 |
F2116368 | Certificate of Analysis | Jun 21, 2021 | S105491 |
Solubility | Soluble in water (50 mg/ml). |
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Specific Rotation[α] | -85° (C=1,H2O) |
Melt Point(°C) | 250 °C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | WK4990000 |
Merck Index | 8826 |
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52. Xiaofei Liao, Mengyan Li, Li Zou. (2022) Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission. RSC Advances, 12 (29): (18296-18300). [PMID:35799941] |
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54. Jian Zhang, Zhijun Bao, Jingjing Qian, Haibo Zhou, Kui Zhang. (2022) Copper doped zinc sulfide quantum dots as ratiometric fluorescent probes for rapid and specific detection of tetracycline residues in milk. ANALYTICA CHIMICA ACTA, 1216 (339991). [PMID:35691678] |
55. Jingjing Li, Long Jiang, Xu Wang, Zhixue Zhu, Qingxin Zhang, Su Liu, Yu Wang, Jiadong Huang. (2022) Ultrasensitive electrochemical aptasensor based on palindromic sequence mediated bidirectional SDA and a DNAzyme walker for kanamycin detection. NEW JOURNAL OF CHEMISTRY, 46 (21): (10394-10401). [PMID:] |
56. Zhi-feng Cai, Hao-yang Li, Xian-song Wang, Can Min, Jia-qi Wen, Rui-xin Fu, Zi-yue Dai, Jing Chen, Ming-zhu Guo, Hui-juan Yang, Ping-ping Bai, Xiao-mi Lu, Tao Wu, Ying Wu. (2022) Highly luminescent copper nanoclusters as temperature sensors and “turn off” detection of oxytetracycline. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 647 (129202). [PMID:] |
57. Xiaojiao Du, Jun Sun, Yan Li, Wenhan Du, Ding Jiang. (2022) Self-accelerated electrochemiluminescence luminophor of Ag3PO4-Ti3C2 for trace lincomycin aptasensing. MICROCHEMICAL JOURNAL, 179 (107578). [PMID:] |
58. Wen Zhao, Ye Xu, Qingkui Guo, Wenliang Qian, Chen Zhu, Min Zheng. (2022) A novel anti-lung cancer agent inhibits proliferation and epithelial–mesenchymal transition. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, [PMID:35477254] |
59. Wang Yang, Jin Daobin, Zhang Xiaoqian, Zhao Jikuan, Hun Xu. (2022) Self-enhancement photoelectrochemical strategy for kanamycin determination with amino functionalized MOFs. MICROCHIMICA ACTA, 189 (5): (1-7). [PMID:35426050] |
60. Xin Wang, Longwen Li, Hong Jiang, Hui Zhangsun, Qinzhi Wang, Xinyu Sun, Li Wang. (2022) Highly selective and sensitive fluorescence detection of tetracyclines based on novel tungsten oxide quantum dots. FOOD CHEMISTRY, 374 (131774). [PMID:34896945] |
61. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang. (2022) Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 634 (127962). [PMID:] |
62. Mengjiao Mo, Xueshen Wang, Lingyue Ye, Yaoquan Su, Yang Zhong, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) A simple paper-based ratiometric luminescent sensor for tetracyclines using copper nanocluster-europium hybrid nanoprobes. ANALYTICA CHIMICA ACTA, 1190 (339257). [PMID:34857135] |
63. Wanling Cui, Guodong Hu, Enguang Lv, Chonghui Li, Zhenxing Wang, Qiang Li, Zhaohong Qian, Jihua Wang, Shicai Xu, Rui Wang. (2022) A label-free and enzyme-free fluorescent aptasensor for amplified detection of kanamycin in milk sample based on target-triggered catalytic hairpin assembly. FOOD CONTROL, 133 (108654). [PMID:] |
64. Wan Huang, Danyan Zhan, Yiming Xie, Xin Li, Guosong Lai. (2022) Dual CHA-mediated high-efficient formation of a tripedal DNA walker for constructing a novel proteinase-free dual-mode biosensing strategy. BIOSENSORS & BIOELECTRONICS, 197 (113708). [PMID:34763154] |
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42. Bu Yiming, Yin Ranhao, Yu Long, Su Pengchen, Li Zibiao, Ye Enyi, Loh Xian Jun, Zhu Houjuan, Wang Suhua. (2022) Paper-based device for the selective determination of doxycycline antibiotic based on the turn-on fluorescence of bovine serum albumin–coated copper nanoclusters. MICROCHIMICA ACTA, 189 (11): (1-10). [PMID:36217040] |
43. Yan Liu, Baibing Guan, Ziqi Xu, Yaohui Wu, Yonghong Wang, Ge Ning. (2023) A fluorescent assay for sensitive detection of kanamycin by split aptamers and DNA-based copper/silver nanoclusters. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 286 (121953). [PMID:36242838] |
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50. Yuyu Zhao, Long Bai, Yi Zhang, Runhua Yao, Yonghua Sun, Ruiyue Hang, Xiangyang Chen, Huaiyu Wang, Xiaohong Yao, Yin Xiao, Ruiqiang Hang. (2022) Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis. BIOMATERIALS, 288 (121684). [PMID:35995624] |
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55. Jingjing Li, Long Jiang, Xu Wang, Zhixue Zhu, Qingxin Zhang, Su Liu, Yu Wang, Jiadong Huang. (2022) Ultrasensitive electrochemical aptasensor based on palindromic sequence mediated bidirectional SDA and a DNAzyme walker for kanamycin detection. NEW JOURNAL OF CHEMISTRY, 46 (21): (10394-10401). [PMID:] |
56. Zhi-feng Cai, Hao-yang Li, Xian-song Wang, Can Min, Jia-qi Wen, Rui-xin Fu, Zi-yue Dai, Jing Chen, Ming-zhu Guo, Hui-juan Yang, Ping-ping Bai, Xiao-mi Lu, Tao Wu, Ying Wu. (2022) Highly luminescent copper nanoclusters as temperature sensors and “turn off” detection of oxytetracycline. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 647 (129202). [PMID:] |
57. Xiaojiao Du, Jun Sun, Yan Li, Wenhan Du, Ding Jiang. (2022) Self-accelerated electrochemiluminescence luminophor of Ag3PO4-Ti3C2 for trace lincomycin aptasensing. MICROCHEMICAL JOURNAL, 179 (107578). [PMID:] |
58. Wen Zhao, Ye Xu, Qingkui Guo, Wenliang Qian, Chen Zhu, Min Zheng. (2022) A novel anti-lung cancer agent inhibits proliferation and epithelial–mesenchymal transition. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, [PMID:35477254] |
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60. Xin Wang, Longwen Li, Hong Jiang, Hui Zhangsun, Qinzhi Wang, Xinyu Sun, Li Wang. (2022) Highly selective and sensitive fluorescence detection of tetracyclines based on novel tungsten oxide quantum dots. FOOD CHEMISTRY, 374 (131774). [PMID:34896945] |
61. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang. (2022) Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 634 (127962). [PMID:] |
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64. Wan Huang, Danyan Zhan, Yiming Xie, Xin Li, Guosong Lai. (2022) Dual CHA-mediated high-efficient formation of a tripedal DNA walker for constructing a novel proteinase-free dual-mode biosensing strategy. BIOSENSORS & BIOELECTRONICS, 197 (113708). [PMID:34763154] |