Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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S102408-1mg | 1mg | In stock | $513.90 |
Synonyms | streptonigrin | Bruneomycin | Rufocromomycin | Nigrin | 3930-19-6 | Streptonigran | Rufocromomycine | Valacidin | NSC-45383 | Rufocromomicina | Rufocromomycinum | Abbott Crystalline antibiotic | Streptonigrin [USAN] | NSC 45383 | NSC45383 | Antibiotic from Streptomyces flocculus | Rufoc |
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Specifications & Purity | Moligand™, ≥95% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of peptidyl arginine deiminase 3;Inhibitor of peptidyl arginine deiminase 4 |
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IUPAC Name | 5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid |
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INCHI | InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34) |
InChi Key | PVYJZLYGTZKPJE-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(=C(N=C1C(=O)O)C2=NC3=C(C=C2)C(=O)C(=C(C3=O)N)OC)N)C4=C(C(=C(C=C4)OC)OC)O |
Isomeric SMILES | CC1=C(C(=C(N=C1C(=O)O)C2=NC3=C(C=C2)C(=O)C(=C(C3=O)N)OC)N)C4=C(C(=C(C=C4)OC)OC)O |
WGK Germany | 3 |
RTECS | TJ7350000 |
PubChem CID | 5298 |
UN Number | 3462 |
Molecular Weight | 506.46 |
Beilstein | 599390 |
PubChem CID | 5298 |
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Wikipedia | Streptonigrin |
CAS Registry No. | 3930-19-6 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | TJ7350000 |
1. Severina IS, Pyatakova NV, Postnikov AB, Preobrazhenskaya MN, Khropov YV. (2004) Antitumor antibiotic streptonigrin and its derivatives as inhibitors of nitric oxide-dependent activation of soluble guanylyl cyclase.. Eur J Pharmacol, 483 (2-3): (127-32). [PMID:14729099] |
2. Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. (2010) A fluopol-ABPP HTS assay to identify PAD inhibitors.. Chem Commun (Camb.), 46 (38): (7175-7). [PMID:20740228] |
3. Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. (2014) Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.. Bioorg Med Chem, 22 (4): (1362-9). [PMID:24440480] |