Grouped product items

SKU

Size

Availability

Price

Qty

S275288-5mg

5mg

Available within 4-8 weeks(?)

$9.90

S275288-10mg

10mg

Available within 4-8 weeks(?)

$12.90

S275288-25mg

25mg

Available within 4-8 weeks(?)

$24.90

S275288-50mg

50mg

Available within 4-8 weeks(?)

$37.90

S275288-100mg

100mg

Available within 4-8 weeks(?)

$57.90

Basic Description

Synonyms	Strychnidin-10-one, monohydrochloride \| Strychnine Hydrochloride Hydrate \| CHEBI:90699 \| STRYCHNINE HYDROCHLORIDE [WHO-DD] \| CCG-208325 \| Strychnine, monohydrochloride \| D92242 \| SCHEMBL184168 \| Strychnine hydrochloride \| STRYCHNINE HYDROCHLORIDE, (-)- \|
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Competitive glycine receptor antagonist. Convulsant. Also antagonist at α7 receptors and α4β2 nicotinic receptors.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Application： Strychnine Hydrochloride acts as an antagonist for cholinesterases and beta amyloid aggregation.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one;hydrochloride
INCHI	InChI=1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
InChi Key	VLXYTKMPCOQKEM-ZEYGOCRCSA-N
Canonical SMILES	C1CN2CC3=CCOC4CC(=O)N5C6C4C3CC2C61C7=CC=CC=C75.Cl
Isomeric SMILES	C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C@H]3C[C@H]2[C@@]61C7=CC=CC=C75.Cl
PubChem CID	16219987
Molecular Weight	370.87

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
J2412083	Certificate of Analysis	Oct 15, 2024	S275288
H2416037	Certificate of Analysis	Aug 22, 2024	S275288
G2408049	Certificate of Analysis	Jan 09, 2024	S275288
F2220466	Certificate of Analysis	Apr 12, 2023	S275288
F2220467	Certificate of Analysis	Apr 12, 2023	S275288
F2220402	Certificate of Analysis	Apr 12, 2023	S275288
F2220458	Certificate of Analysis	Apr 12, 2023	S275288
F2220452	Certificate of Analysis	Jun 21, 2022	S275288

Chemical and Physical Properties

Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Sensitivity	Moisture sensitive
Melt Point(°C)	>235°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09
Signal	Danger
Hazard Statements	H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H300:Fatal if swallowed H330:Fatal if inhaled
Precautionary Statements	P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wu Jun, Zhao Miao, Jin Yu-chen, Li Min, Yu Ke-xin, Yu Hai-bo. (2023) Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models. ACTA PHARMACOLOGICA SINICA, (11): (1-15). [PMID:38017298] [10.1038/s41401-023-01195-3]

References

1. Brownjohn PW et al.. (2017) Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.. Stem Cell Reports, 8 (4): (870-882). [PMID:28285880]
2. Breton-Provencher V & Sur M. (2019) Active control of arousal by a locus coeruleus GABAergic circuit.. Nat Neurosci, 22 (2): (218-228). [PMID:30643295]
3. Tagoe T et al.. (2014) Auditory nerve perinodal dysmyelination in noise-induced hearing loss.. J Neurosci, 34 (7): (2684-8). [PMID:24523557]
4. McGee TP et al.. (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.. J Neurosci, 35 (49): (16171-9). [PMID:26658868]
5. Bender KJ & Trussell LO. (2009) Axon initial segment Ca2+ channels influence action potential generation and timing.. Neuron, 61 (2): (259-71). [PMID:19186168]
6. Zonouzi M et al.. (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.. Nat Neurosci, 14 (11): (1430-8). [PMID:21983683]
7. Turecek J & Regehr WG. (2020) Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters.. Elife, 9 [PMID:33259288]
8. Husson Z et al.. (2014) Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.. J Neurosci, 34 (28): (9418-31). [PMID:25009273]
9. Raja MK et al.. (2019) Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.. Elife, 8 [PMID:31090538]
10. Roberts MT et al.. (2008) Fidelity of complex spike-mediated synaptic transmission between inhibitory interneurons.. J Neurosci, 28 (38): (9440-50). [PMID:18799676]
11. Suárez F et al.. (2010) Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones.. Eur J Neurosci, 32 (3): (359-67). [PMID:20618827]
12. Alamilla J & Gillespie DC. (2011) Glutamatergic inputs and glutamate-releasing immature inhibitory inputs activate a shared postsynaptic receptor population in lateral superior olive.. Neuroscience, 196 (285-96). [PMID:21907763]
13. Chiu SL et al.. (2017) GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors.. Neuron, 93 (6): (1405-1419.e8). [PMID:28285821]
14. Fekete CD et al.. (2017) In vivo transgenic expression of collybistin in neurons of the rat cerebral cortex.. J Comp Neurol, 525 (5): (1291-1311). [PMID:27804142]
15. Khan MM & Regehr WG. (2020) Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions.. Elife, 9 [PMID:32347796]
16. Anderson CT et al.. (2015) Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc.. Proc Natl Acad Sci U S A, 112 (20): (E2705-14). [PMID:25947151]
17. Li J et al.. (2017) Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.. Neuron, 96 (4): (808-826.e8). [PMID:29107521]
18. Yue HY & Xu J. (2014) Myosin light chain kinase accelerates vesicle endocytosis at the calyx of Held synapse.. J Neurosci, 34 (295-304). [PMID:24381290]
19. Lin YS et al.. (2016) Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis.. PLoS One, 11 (10): (e0164164). [PMID:27701470]
20. St Laurent R et al.. (2020) Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity.. Neuron, 106 (4): (624-636.e4). [PMID:32191871]
21. Guo C et al.. (2021) Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex.. Elife, 10 [PMID:34369877]
22. Wang HY et al.. (2015) RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function.. Sci Rep, 5 (17383). [PMID:26619789]
23. Kuo SP & Trussell LO. (2011) Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition.. Neuron, 71 (2): (306-18). [PMID:21791289]
24. Studniarczyk D et al.. (2013) TARP ?-7 selectively enhances synaptic expression of calcium-permeable AMPARs.. Nat Neurosci, 16 (9): (1266-74). [PMID:23872597]
25. Bertollini C et al.. (2012) Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells.. Front Mol Neurosci, 5 (100). [PMID:23189038]
26. Wu Jun, Zhao Miao, Jin Yu-chen, Li Min, Yu Ke-xin, Yu Hai-bo. (2023) Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models. ACTA PHARMACOLOGICA SINICA, (11): (1-15). [PMID:38017298] [10.1038/s41401-023-01195-3]

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Strychnine hydrochloride - ≥99%, high purity , CAS No.1421-86-9

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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SKU	Size	Availability	Price
S275288-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9.90
S275288-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$12.90
S275288-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$24.90
S275288-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$37.90
S275288-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$57.90