Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H671079-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $89.90 | |
H671079-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $349.90 | |
H671079-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $559.90 | |
H671079-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $899.90 |
Synonyms | (S,Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide | SU 014813 | SU-14813 |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | SU14813 (SU 014813) is a multi receptor tyrosine kinase inhibitor with IC50 values of 50 nM, 2 nM, 4 nM, and 15 nM for VEGFR2, VEGFR1, PDGFR β, and Kit (c-Kit), respectively. SU14813 has strong anti angiogenic and anti-tumor activity. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Tyrosine-protein kinase receptor FLT3 inhibitor |
ALogP | 0.9 |
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IUPAC Name | 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
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INCHI | InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 |
InChi Key | CTNPALGJUAXMMC-PMFHANACSA-N |
Canonical SMILES | CC1=C(NC(=C1C(=O)NCC(CN2CCOCC2)O)C)C=C3C4=C(C=CC(=C4)F)NC3=O |
Isomeric SMILES | CC1=C(NC(=C1C(=O)NC[C@@H](CN2CCOCC2)O)C)/C=C\3/C4=C(C=CC(=C4)F)NC3=O |
PubChem CID | 10138259 |
Molecular Weight | 442.48 |
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Solubility | DMSO : 88 mg/mL ( (198.87 mM) ;Water : Insoluble;Ethanol : Insoluble |
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