SU11274 - ≥97%, high purity , CAS No.658084-23-2, Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Item Number

S126117

• Synonyms: BDBM50341636 | (3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piper
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: SU11274 is selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). SU11274 reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogen
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Product Description

application：

SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3

           SU11274 has been used:

           To study the role of hepatocyte growth factor (HGF) in human vestibular schwannoma proliferation.

           To study its effect on human gastric carcinoma cell line MKN-45.

           To study the effect of HGF on phosphorylation of epidermal growth factor receptor, c-Met and other signaling pathways.