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SU11274 - ≥97%, high purity , CAS No.658084-23-2, Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Moligand™
≥97%

CAS#: 658084-23-2
Formula: C₂₈H₃₀CIN₅O₄S
Molecular Weight: 568.09
MDL number: MFCD08276928
PubChem CID: 9549297
PubChem SID: 488196274

Item Number

S126117

Grouped product items
SKU	Size	Availability	Price
S126117-5mg	5mg	In stock	$118.90
S126117-10mg	10mg	In stock	$184.90
S126117-25mg	25mg	In stock	$369.90
S126117-50mg	50mg	In stock	$597.90
S126117-100mg	100mg	In stock	$924.90
S126117-250mg	250mg	In stock	$2,081.90

View related series

MET proto-oncogene，receptor tyrosine kinase Inhibitor

Basic Description

Synonyms	SU11274\|658084-23-2\|Met Kinase Inhibitor\|SU-11274\|PKI-SU11274\|SU 11274\|SU-MI-2\|CHEMBL261641\|(3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide\|(3Z)-N-(
Specifications & Purity	≥97%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MET proto-oncogene; receptor tyrosine kinase
Product Description	application： SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3 SU11274 has been used: To study the role of hepatocyte growth factor (HGF) in human vestibular schwannoma proliferation. To study its effect on human gastric carcinoma cell line MKN-45. To study the effect of HGF on phosphorylation of epidermal growth factor receptor, c-Met and other signaling pathways.

Associated Targets

PTK2B Tclin Protein-tyrosine kinase 2-beta 1 Activities

Discover Target: PTK2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 5 Activities

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488196274
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488196274
IUPAC Name	(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
INCHI	InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
InChi Key	FPYJSJDOHRDAMT-KQWNVCNZSA-N
Canonical SMILES	CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
Isomeric SMILES	CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
WGK Germany	3
PubChem CID	9549297
Molecular Weight	568.09

CAS Registry No.

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
C2320253	Certificate of Analysis	Dec 20, 2022	S126117
C2320254	Certificate of Analysis	Dec 20, 2022	S126117
C2320255	Certificate of Analysis	Dec 20, 2022	S126117
C2320339	Certificate of Analysis	Dec 20, 2022	S126117
C2320348	Certificate of Analysis	Dec 20, 2022	S126117
C2320351	Certificate of Analysis	Dec 20, 2022	S126117
C2320359	Certificate of Analysis	Dec 20, 2022	S126117
C2320398	Certificate of Analysis	Dec 20, 2022	S126117
C2320402	Certificate of Analysis	Dec 20, 2022	S126117
C2320403	Certificate of Analysis	Dec 20, 2022	S126117
C2320404	Certificate of Analysis	Dec 20, 2022	S126117
C2320742	Certificate of Analysis	Dec 20, 2022	S126117

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

References

1. Longati P, Comoglio PM, Bardelli A. (2001) Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.. Curr Drug Targets, 2 (1): (41-55). [PMID:11465538]
2. Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R. (2002) Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.. Cytokine Growth Factor Rev, 13 (1): (41-59). [PMID:11750879]
3. Haddad R, Lipson KE, Webb CP. (2001) Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors.. Anticancer Res, 21 (6B): (4243-52). [PMID:11908677]
4. Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S et al.. (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.. Mol Cancer Ther, 2 (11): (1085-92). [PMID:14617781]

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