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SU5416 - ≥98% (HPLC), high purity , CAS No.204005-46-9

≥98%(HPLC)

CAS#: 204005-46-9
Formula: C₁₅H₁₄N₂O
Molecular Weight: 238.28
MDL number: MFCD01940922
PubChem CID: 5329098

Item Number

S125835

Grouped product items
SKU	Size	Availability	Price
S125835-10mg	10mg	In stock	$19.90
S125835-50mg	50mg	In stock	$62.90
S125835-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$210.90
S125835-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$568.90

Selective VEGFR-2 inhibitor

Basic Description

Synonyms	Semaxanib\|Semaxinib\|SU5416\|204005-46-9\|SU 5416\|194413-58-6\|SU-5416\|Semoxind\|Semaxanib (SU5416)\|(Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one\|TSU 16\|NSC-696819\|VEGFR2 Kinase Inhibitor III\|(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-i
Specifications & Purity	≥98% (HPLC)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. It was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain，and study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.

Associated Targets

PDGFRB Tclin Platelet-derived growth factor receptor beta 0 Activities

Discover Target: PDGFRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

Discover Target: FLT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
INCHI	InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChi Key	WUWDLXZGHZSWQZ-WQLSENKSSA-N
Canonical SMILES	CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
Isomeric SMILES	CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C
WGK Germany	3
PubChem CID	5329098
Molecular Weight	238.28

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
F2220404	Certificate of Analysis	Apr 03, 2024	S125835
F2220405	Certificate of Analysis	Apr 03, 2024	S125835
F2220491	Certificate of Analysis	Apr 03, 2024	S125835
F2220534	Certificate of Analysis	Apr 03, 2024	S125835
J2326596	Certificate of Analysis	Oct 08, 2023	S125835
J2326597	Certificate of Analysis	Oct 08, 2023	S125835
J2326606	Certificate of Analysis	Oct 08, 2023	S125835
G2120352	Certificate of Analysis	May 09, 2023	S125835

Solubility

Soluble in DMSO (5 mg/ml), and ethanol (100 mM). Insoluble in water.

Melt Point(°C)

221-222°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

References

1. Chang SH et al.. (2019) Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-?B pathway.. Nat Commun, 10 (1442). [PMID:30926814]
2. Fan XX et al.. (2022) Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.. Front Pharmacol, 13 (968124). [PMID:36091747]
3. Tanaka H et al.. (2017) Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension.. PLoS One, 12 (7): (e0180615). [PMID:28686688]

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